{"id":"W2770825924","doi":"10.1513/annalsats.201708-694rl","title":"Clinical Experience with <i>SERPINA1</i> DNA Sequencing to Detect Alpha-1 Antitrypsin Deficiency","year":2017,"lang":"en","type":"letter","venue":"Annals of the American Thoracic Society","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Alpha 1-antitrypsin deficiency; Medicine; Alpha (finance); DNA sequencing; Genetics; Immunology; DNA; Clinical psychology; Biology; Psychometrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001174158,0.0008300894,0.0004730591,0.0005098155,0.00121059,0.001111128,0.0007727561,0.005704901,0.001727764],"category_scores_gemma":[0.008578313,0.0003694392,0.000570316,0.0004331861,0.001183773,0.001205368,0.0005350729,0.004962673,0.001388445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007897331,"about_ca_system_score_gemma":0.0005435575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007095081,"about_ca_topic_score_gemma":0.001117714,"domain_scores_codex":[0.9990515,0.0003161038,0.0001043144,0.0001681218,0.0001482547,0.0002116453],"domain_scores_gemma":[0.9963453,0.002045001,0.0002651579,0.000170222,0.0004397106,0.0007346179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0002390507,0.0001618208,0.0240862,0.00006759146,0.0000287791,0.8918281,0.0008197902,0.0003319647,0.00331393,0.001280588,0.0606555,0.01718673],"study_design_scores_gemma":[0.00008925577,0.0003658161,0.005029827,0.00008276052,0.00003323471,0.9555405,0.0003792965,0.0008823581,0.001890048,0.002676085,0.03299889,0.00003184419],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3513238,0.009152411,0.007672875,0.5393191,0.01325718,0.0001741378,0.0002564532,0.0003998268,0.07844421],"genre_scores_gemma":[0.8113992,0.004193268,0.003245013,0.153793,0.01689789,0.00005695843,0.000162649,0.000166709,0.01008523],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.005704901,"threshold_uncertainty_score":0.006209612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0891051817119422,"score_gpt":0.4006449933621444,"score_spread":0.3115398116502022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}