{"id":"W2770845572","doi":"10.1038/s41598-017-16219-2","title":"17β-Estradiol sensitizes ovarian surface epithelium to transformation by suppressing Disabled-2 expression","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"Estrogen; Ovarian cancer; Cancer research; Epithelium; Ovary; Biology; microRNA; Malignant transformation; Oncogene; Cancer; Internal medicine; Endocrinology; Medicine; Cell cycle; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092622,0.000174824,0.0001628651,0.0001808897,0.0001021371,0.0002847334,0.00009237541,0.0001217448,0.001386597],"category_scores_gemma":[0.00008890289,0.0001088813,0.0002142443,0.00009215791,0.0001541561,0.0001264321,0.0002017047,0.0002777388,0.0002813578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001240911,"about_ca_system_score_gemma":0.0001463034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002806409,"about_ca_topic_score_gemma":0.0005873294,"domain_scores_codex":[0.9999222,0.0000121938,0.000007368832,0.00001430425,0.00002088966,0.00002309559],"domain_scores_gemma":[0.9999412,0.00001057176,0.0000164901,0.00001237559,0.000005453204,0.00001394282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005121608,0.00001161747,0.0004666251,0.00001612509,0.000003353102,0.00004729987,0.00001352577,0.00002329086,0.9979066,0.00008054055,0.00002172575,0.00135812],"study_design_scores_gemma":[0.00001066485,0.0001962805,0.006511524,0.000003327128,0.000007353177,0.0004019127,0.00003779257,0.0002068585,0.9872205,0.00004197414,0.005359146,0.000002626731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948992,0.00134556,0.001663877,0.00007475585,0.00002647199,0.00001689396,0.0001897999,0.00005467289,0.001728816],"genre_scores_gemma":[0.9947001,0.001160457,0.0009014966,0.0000342813,0.000004830619,0.00001306177,0.000245754,0.00001462129,0.002925451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386597,"threshold_uncertainty_score":0.004638553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009599601810370588,"score_gpt":0.2563063941528549,"score_spread":0.2467067923424843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}