{"id":"W2770879807","doi":"10.1534/genetics.117.300268","title":"Cooperative Control of Ecdysone Biosynthesis in <i>Drosophila</i> by Transcription Factors Séance, Ouija Board, and Molting Defective","year":2017,"lang":"en","type":"article","venue":"Genetics","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Alberta","funders":"Precursory Research for Embryonic Science and Technology; Canadian Institutes of Health Research; Japan Science and Technology Agency; Institute of Genetics; Natural Sciences and Engineering Research Council of Canada; Japan Society for the Promotion of Science","keywords":"Biology; Ecdysone; Drosophila melanogaster; Zinc finger; Transcription factor; Prothoracic gland; Zinc finger transcription factor; Gene; Transcription (linguistics); Genetics; Cell biology; Ecdysone receptor; Ecdysterone; Nuclear receptor; Hormone; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453634,0.0004325385,0.000220075,0.0003414649,0.0002229935,0.0003749295,0.0002604699,0.0001336227,0.0006306631],"category_scores_gemma":[0.0001477859,0.0002359294,0.0001988691,0.000105392,0.0003537487,0.0001272362,0.0006291493,0.0002792999,0.0002155072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008752913,"about_ca_system_score_gemma":0.0002042162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00245344,"about_ca_topic_score_gemma":0.006479644,"domain_scores_codex":[0.9997746,0.00001978635,0.0000164043,0.00008063002,0.00006689566,0.0000416582],"domain_scores_gemma":[0.9997892,0.00002998151,0.00007107776,0.00002529712,0.00001894817,0.00006555413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003361588,0.00000510392,0.0007441608,0.00001042005,0.000001930815,0.00003431733,0.00001576367,0.00004558081,0.9982539,0.00006807083,0.00002417751,0.0007630293],"study_design_scores_gemma":[0.00003896271,0.00012727,0.05447413,0.00001026732,0.00001860001,0.0003642214,0.0001141626,0.003377905,0.9374521,0.0000805743,0.00392788,0.00001391451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995801,0.0006600847,0.001760537,0.00002891381,0.000009987086,0.00001303758,0.0001213086,0.0001064107,0.00149871],"genre_scores_gemma":[0.9965101,0.0001312828,0.001244565,0.00003131175,0.000003534467,0.00001495953,0.0002309789,0.0000305054,0.001802774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00245344,"threshold_uncertainty_score":0.006350756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03079520223440419,"score_gpt":0.2818701928253196,"score_spread":0.2510749905909154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}