{"id":"W2770879807","doi":"10.1534/genetics.117.300268","title":"Cooperative Control of Ecdysone Biosynthesis in <i>Drosophila</i> by Transcription Factors Séance, Ouija Board, and Molting Defective","year":2017,"lang":"en","type":"article","venue":"Genetics","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Alberta","funders":"Precursory Research for Embryonic Science and Technology; Canadian Institutes of Health Research; Japan Science and Technology Agency; Institute of Genetics; Natural Sciences and Engineering Research Council of Canada; Japan Society for the Promotion of Science","keywords":"Biology; Ecdysone; Drosophila melanogaster; Zinc finger; Transcription factor; Prothoracic gland; Zinc finger transcription factor; Gene; Transcription (linguistics); Genetics; Cell biology; Ecdysone receptor; Ecdysterone; Nuclear receptor; Hormone; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377635,0.0001297158,0.0002510262,0.00007472017,0.0003073141,0.00002445933,0.0002403982,0.000111417,0.000008699561],"category_scores_gemma":[0.0004667134,0.0001133143,0.00003683913,0.00007836587,0.0007001545,0.0000973139,0.00005418388,0.0001869901,0.000003110835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001066301,"about_ca_system_score_gemma":0.00002241677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002162726,"about_ca_topic_score_gemma":0.00003393289,"domain_scores_codex":[0.9988391,0.0002726157,0.000177418,0.0003475267,0.00008311696,0.0002802107],"domain_scores_gemma":[0.9992142,0.0003322596,0.0001159358,0.0002510526,0.00003852537,0.00004796758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008890214,0.00005774217,0.03765612,0.00001002516,0.000006055123,0.000002647042,0.0002681527,0.00003794054,0.9615041,0.0001219085,0.00002581735,0.0002206079],"study_design_scores_gemma":[0.0007002525,0.0002681741,0.05717281,0.00001302363,0.000008154113,0.000002297998,0.0000439025,0.0004089909,0.9409345,0.0002825818,0.00006402753,0.0001012662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988238,0.0001579726,0.0000736041,0.0001455473,0.00008630369,0.000258782,0.0001239435,0.00001003652,0.0003199617],"genre_scores_gemma":[0.9994026,0.0003432906,0.00002147008,0.0001520029,0.0000173567,0.00001315891,0.000001536628,0.00001092852,0.00003762108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02056957,"threshold_uncertainty_score":0.4620824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03079520223440419,"score_gpt":0.2818701928253196,"score_spread":0.2510749905909154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}