{"id":"W2770901331","doi":"10.1097/wnr.0000000000000922","title":"Overexpressed wild-type superoxide dismutase 1 exhibits amyotrophic lateral sclerosis-related misfolded conformation in induced pluripotent stem cell-derived spinal motor neurons","year":2017,"lang":"en","type":"article","venue":"Neuroreport","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Induced pluripotent stem cell; Transgene; Mutant; Biology; Genetically modified mouse; Motor neuron; Cell biology; Superoxide dismutase; Mutation; Wild type; Neuroscience; Spinal cord; Genetics; Medicine; Pathology; Gene; Endocrinology; Embryonic stem cell; Oxidative stress; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003535489,0.0005317262,0.0007935945,0.0003311912,0.0004522196,0.0002316308,0.0005465482,0.0003506708,0.0001955232],"category_scores_gemma":[0.0002935792,0.0004693686,0.000243475,0.0002736479,0.0002347728,0.0009234931,0.0003829832,0.001121376,0.0001581359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519891,"about_ca_system_score_gemma":0.0003872153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007600057,"about_ca_topic_score_gemma":0.00002575202,"domain_scores_codex":[0.9953809,0.0001961015,0.001337697,0.0009113594,0.001199525,0.0009744673],"domain_scores_gemma":[0.9966315,0.00004274537,0.0006723292,0.001725642,0.0003194194,0.0006083404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001368379,0.0003544271,0.04496462,0.0001237725,0.00004375663,0.001750025,0.0002416369,0.00004193907,0.9497437,0.000008824293,0.0002625841,0.001096339],"study_design_scores_gemma":[0.00518985,0.001334755,0.9155747,0.000424598,0.00006935378,0.000247406,0.00003460096,0.002123001,0.07442228,0.00002095307,0.0001604901,0.0003979845],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950184,0.00005868288,0.000003403572,0.00173574,0.0005811553,0.001660065,0.00002113598,0.0001825217,0.0007388759],"genre_scores_gemma":[0.9981294,0.0001703125,0.00006175738,0.0004510569,0.000133037,0.00008413659,0.00009905089,0.0001068766,0.000764356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8753214,"threshold_uncertainty_score":0.9997758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06405097857903373,"score_gpt":0.2952809805639268,"score_spread":0.2312300019848931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}