{"id":"W2770943412","doi":"10.3389/fnins.2017.00647","title":"The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic Implications","year":2017,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Huntingtin; Mutant; Seeding; Cell biology; In vitro; Biology; Neuroscience; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005655683,0.000773239,0.001031005,0.001934546,0.0002257622,0.000906901,0.000669191,0.0009190658,0.002304779],"category_scores_gemma":[0.000560137,0.0002420184,0.0004203337,0.001258226,0.000565918,0.001108047,0.0006450173,0.001435355,0.001549156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005271841,"about_ca_system_score_gemma":0.0007470153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007452793,"about_ca_topic_score_gemma":0.001134506,"domain_scores_codex":[0.9998103,0.00003104891,0.00003004695,0.00003574799,0.00007536001,0.00001758485],"domain_scores_gemma":[0.9996667,0.0001806727,0.00003523814,0.00001409575,0.00008509292,0.00001818441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00008994891,0.00009706375,0.0002644888,0.02950074,0.0001014797,0.0004249966,0.0001851029,0.0005705186,0.02269094,0.009397461,0.01242246,0.9242548],"study_design_scores_gemma":[0.00001101898,0.000130685,0.0008770015,0.003226907,0.0001084208,0.001862916,0.00009178029,0.00008406938,0.00763996,0.002138173,0.9838021,0.00002698629],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004210563,0.9966167,0.0003055626,0.0001509955,0.000165652,0.000006161876,0.00003225825,0.000008840726,0.002292818],"genre_scores_gemma":[0.001344806,0.997677,0.0002880477,0.00008225753,0.00006561108,0.000006884416,0.00003852984,0.000002124408,0.000494792],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002304779,"threshold_uncertainty_score":0.007710278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2140426688119267,"score_gpt":0.3673290465192548,"score_spread":0.1532863777073281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}