{"id":"W2770954695","doi":"10.1093/nar/gkx832","title":"Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B","year":2017,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Cytidine deaminase; Biology; APOBEC; DNA; Mutagenesis; DNA replication; Cytidine; Activation-induced (cytidine) deaminase; Cytosine deaminase; Enzyme; Biochemistry; Molecular biology; Genetics; Genome; Gene; Mutation; Somatic hypermutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142727,0.0002501805,0.0002744602,0.0001764735,0.0001213075,0.0004110799,0.0002064063,0.0003096466,0.0009615078],"category_scores_gemma":[0.0004170342,0.0001938794,0.0001609558,0.0001221551,0.0002143391,0.0002321619,0.000288055,0.0005014698,0.0004200612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003314995,"about_ca_system_score_gemma":0.000321941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218724,"about_ca_topic_score_gemma":0.001263694,"domain_scores_codex":[0.9997789,0.00004532665,0.00001550363,0.00005133675,0.00005878669,0.00005022062],"domain_scores_gemma":[0.9997832,0.00007117284,0.00003528964,0.00003581083,0.00002955189,0.00004491796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003112494,0.00001163978,0.0001467489,0.000009376593,0.000001182754,0.00001238321,0.000004129163,0.00003606581,0.9985423,0.00006462572,0.000008523321,0.001131979],"study_design_scores_gemma":[0.000005126621,0.00007216272,0.00250831,0.000002877436,0.000003833102,0.0001499156,0.000009113627,0.001804865,0.9945579,0.00007706513,0.0008060785,0.000002938016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897087,0.001299122,0.007416241,0.00007665691,0.00001559541,0.00002628483,0.0000972238,0.0001114327,0.00124875],"genre_scores_gemma":[0.9966975,0.0002448233,0.002144435,0.00001534573,0.000002582336,0.00000889833,0.0001289314,0.00002727762,0.0007301377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218724,"threshold_uncertainty_score":0.003216565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04241683228661803,"score_gpt":0.3541226831727955,"score_spread":0.3117058508861775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}