{"id":"W2771020006","doi":"10.3389/fimmu.2017.01670","title":"Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid","year":2017,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Children's Hospital","funders":"National Institute of Mental Health; National Institutes of Health; Arkansas Biosciences Institute; Autism Research Institute","keywords":"Neurotypical; Metabolite; Microbiome; Modulation (music); Biology; Chemistry; Immunology; Autism; Biochemistry; Medicine; Bioinformatics; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001601959,0.0001461172,0.0002726339,0.00007893034,0.0001258249,0.00002003274,0.0003646864,0.0002552455,0.00000324355],"category_scores_gemma":[0.00007832976,0.0001126501,0.00004501799,0.00005499469,0.0005153785,0.000007550335,0.0002483391,0.000172051,0.000001609087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002680207,"about_ca_system_score_gemma":0.00006365518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006554687,"about_ca_topic_score_gemma":0.00002233228,"domain_scores_codex":[0.9988875,0.0001642791,0.000314153,0.0003095759,0.00003514963,0.0002893775],"domain_scores_gemma":[0.9992981,0.000007664129,0.0001920929,0.0004573892,0.00002727024,0.0000174653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002249776,0.00009734999,0.01752243,0.00002089438,0.00001824395,0.000002229137,0.00007299797,0.000002841389,0.9774379,0.00004514841,0.0003195445,0.004235505],"study_design_scores_gemma":[0.002224531,0.0004719619,0.8042091,0.00002286408,0.00001405725,0.00005039365,0.0001198843,0.0001879916,0.1827182,0.0002810413,0.00949411,0.0002058255],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804443,0.01742348,0.0009250985,0.0003591309,0.0005168256,0.0002532232,0.00003438779,0.000004499579,0.00003906027],"genre_scores_gemma":[0.9961938,0.002490433,0.0009890147,0.00008168756,0.00002269839,0.00002151489,0.00006914197,0.00001162731,0.0001200745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7947196,"threshold_uncertainty_score":0.4593739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007731612248129951,"score_gpt":0.2209355401789216,"score_spread":0.2132039279307917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}