{"id":"W2771170277","doi":"10.1021/acs.langmuir.7b03168","title":"Self-Assembled Ligands Targeting TLR7: A Molecular Level Investigation","year":2017,"lang":"en","type":"article","venue":"Langmuir","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Health Economics","funders":"Kommission für Technologie und Innovation","keywords":"Pharmacophore; Chemistry; TLR7; Cytotoxicity; Phospholipid; Polyethylene glycol; Internalization; Biophysics; Dynamic light scattering; Biochemistry; Combinatorial chemistry; Receptor; Toll-like receptor; Innate immune system; Membrane; In vitro; Biology; Nanotechnology; Nanoparticle; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693789,0.0002343185,0.0001620191,0.0001249329,0.0001211064,0.0001843005,0.0002445658,0.0003407724,0.000517976],"category_scores_gemma":[0.0001919052,0.0001002718,0.0001641099,0.00009183674,0.0001553092,0.0002991514,0.0001654283,0.0003971923,0.000242974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002152987,"about_ca_system_score_gemma":0.0001060141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001376061,"about_ca_topic_score_gemma":0.0001719305,"domain_scores_codex":[0.9999115,0.00002227558,0.000003892637,0.00001394679,0.00002972773,0.00001864623],"domain_scores_gemma":[0.999923,0.00002177793,0.00001537643,0.000006462784,0.00002255944,0.00001090633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003672752,0.00004660503,0.00005453359,0.00007107497,0.000005349149,0.00003264758,0.00001904847,0.0002176309,0.9973425,0.0003170158,0.00004356712,0.001813274],"study_design_scores_gemma":[0.000008937393,0.0004802918,0.0003086434,0.00000782112,0.00001169258,0.00007679175,0.00002083129,0.003286473,0.9937412,0.0000811741,0.00197142,0.000004714358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787764,0.003675208,0.01426503,0.0002500477,0.00004920554,0.00008945817,0.00009778507,0.00006555318,0.002731254],"genre_scores_gemma":[0.9847601,0.00296511,0.009944499,0.000155275,0.00002152486,0.00008243371,0.0001852093,0.00001733252,0.001868578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000517976,"threshold_uncertainty_score":0.001732767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01961371850001309,"score_gpt":0.2506919470305387,"score_spread":0.2310782285305256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}