{"id":"W2771290324","doi":"10.1038/s41467-017-02259-9","title":"H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Office of Science; Ministero dello Sviluppo Economico; Deutsche Forschungsgemeinschaft; National Natural Science Foundation of China; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Ontario Genomics; Pfizer; Argonne National Laboratory; U.S. Department of Energy","keywords":"Methylation; Histone; Histone H3; Gene silencing; Biology; Acetylation; Binding site; Genetics; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002960722,0.00008059628,0.0001158327,0.00003271539,0.0002659021,0.0000143953,0.00110103,0.0002911719,0.00001071198],"category_scores_gemma":[0.0002685466,0.00006800102,0.00008424756,0.00009926825,0.0001621061,0.000005607481,0.0003418094,0.0002200417,0.000002432936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001801686,"about_ca_system_score_gemma":0.00005861098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000692559,"about_ca_topic_score_gemma":0.0003890971,"domain_scores_codex":[0.9993283,0.00009739914,0.0002256237,0.000141064,0.0001229569,0.00008472516],"domain_scores_gemma":[0.9965559,0.00004249971,0.0002878704,0.002846617,0.0002364431,0.00003063644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004649357,0.00005701266,0.000858389,0.000007108391,0.00007923516,9.941269e-9,0.0002699553,0.00003853514,0.9608204,0.0006524895,0.03190421,0.005266137],"study_design_scores_gemma":[0.0006588766,0.0001275985,0.04322029,0.00002922898,0.00006262951,0.000001673521,0.000110412,0.0002508643,0.5355433,0.0007030499,0.4191329,0.0001591991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498401,0.01596789,0.0016919,0.0265437,0.0003032984,0.0009026604,0.0003962397,0.00001371176,0.004340472],"genre_scores_gemma":[0.9956407,0.0003969521,0.003018989,0.000172077,0.00004674667,0.00002939669,0.0002590032,0.00001157352,0.000424551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4252771,"threshold_uncertainty_score":0.2773001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518424578159342,"score_gpt":0.3259264465069019,"score_spread":0.3107422007253085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}