{"id":"W2771290324","doi":"10.1038/s41467-017-02259-9","title":"H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Office of Science; Ministero dello Sviluppo Economico; Deutsche Forschungsgemeinschaft; National Natural Science Foundation of China; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Ontario Genomics; Pfizer; Argonne National Laboratory; U.S. Department of Energy","keywords":"Methylation; Histone; Histone H3; Gene silencing; Biology; Acetylation; Binding site; Genetics; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008819184,0.0002449567,0.000255395,0.0001842077,0.0003588856,0.0003019408,0.0003008099,0.000225822,0.002133861],"category_scores_gemma":[0.0001459452,0.0001958922,0.0004194739,0.0001975081,0.0002135866,0.000171795,0.0005021411,0.0003313437,0.0004187336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004869163,"about_ca_system_score_gemma":0.0002034757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001606278,"about_ca_topic_score_gemma":0.002546392,"domain_scores_codex":[0.9998651,0.00001228558,0.000009263872,0.0000434545,0.00003638336,0.00003349734],"domain_scores_gemma":[0.9999167,0.000008130142,0.00002782868,0.000007581972,0.000008927691,0.000030858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347448,0.000006283403,0.001650787,0.00003270381,0.00001383714,0.00006192595,0.00001488944,0.00008082786,0.996997,0.00008205499,0.0000488654,0.0008761532],"study_design_scores_gemma":[0.00001456022,0.00008111124,0.04539289,0.000006226299,0.00002180845,0.0004422862,0.00005901863,0.001638275,0.9503273,0.0001050873,0.001900328,0.00001087818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956354,0.0006238657,0.002527755,0.0000420273,0.00001549,0.000006480035,0.000370461,0.00005536637,0.0007230418],"genre_scores_gemma":[0.9975418,0.0001352756,0.0006524153,0.00002291061,0.000002277184,0.000004265395,0.0005842204,0.00001152197,0.001045451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002133861,"threshold_uncertainty_score":0.00713855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518424578159342,"score_gpt":0.3259264465069019,"score_spread":0.3107422007253085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}