{"id":"W2771382062","doi":"10.1159/000484257","title":"Kallikrein Cleaves C3 and Activates Complement","year":2017,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"Leibniz-Gemeinschaft; Deutsche Forschungsgemeinschaft","keywords":"Kallikrein; Complement system; Plasmin; Classical complement pathway; Alternative complement pathway; Factor XII; Chemistry; Factor H; Proteolysis; Cell biology; Complement factor B; Biochemistry; Contact system; Activator (genetics); Biology; Immune system; Coagulation; Immunology; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006676018,0.0001348633,0.0003251192,0.0001021941,0.0007388683,0.0000922196,0.0006131852,0.00006193005,0.0005524135],"category_scores_gemma":[0.0002926202,0.0001067532,0.00009709166,0.00002126214,0.0002619284,0.0002856612,0.0003441354,0.0003446426,0.00003168627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004093344,"about_ca_system_score_gemma":0.0000481185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002032411,"about_ca_topic_score_gemma":0.00002257667,"domain_scores_codex":[0.9988915,0.0002701127,0.0004843995,0.00008690438,0.00005641023,0.0002106831],"domain_scores_gemma":[0.9982879,0.0001592321,0.0009065214,0.0004458087,0.0001654707,0.00003510468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009352099,0.0005995253,0.1734461,0.0001180604,0.001371719,0.00004505018,0.001145611,0.00000406556,0.7784408,0.002378915,0.01732612,0.02418884],"study_design_scores_gemma":[0.002467143,0.0004093071,0.8648671,0.000239378,0.00008199454,0.0002364066,0.001074297,0.000001843118,0.09108504,0.0009431149,0.03841648,0.0001778992],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950621,0.002087905,0.00002454896,0.0006739856,0.0006290138,0.0001130587,0.00002455409,0.00001067235,0.001374161],"genre_scores_gemma":[0.9993751,0.0001874638,0.00008933156,0.00006236577,0.0000443216,0.00000198146,0.000006872951,0.000009199417,0.0002233599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.691421,"threshold_uncertainty_score":0.604854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03733437031904928,"score_gpt":0.3112886793221463,"score_spread":0.273954309003097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}