{"id":"W2771382062","doi":"10.1159/000484257","title":"Kallikrein Cleaves C3 and Activates Complement","year":2017,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"Leibniz-Gemeinschaft; Deutsche Forschungsgemeinschaft","keywords":"Kallikrein; Complement system; Plasmin; Classical complement pathway; Alternative complement pathway; Factor XII; Chemistry; Factor H; Proteolysis; Cell biology; Complement factor B; Biochemistry; Contact system; Activator (genetics); Biology; Immune system; Coagulation; Immunology; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169508,0.0004161925,0.0002671023,0.0003602093,0.0002927355,0.0004264745,0.000200618,0.0004573835,0.002974062],"category_scores_gemma":[0.0003525931,0.0001065573,0.0004723744,0.0002035628,0.0002902585,0.0003202314,0.0004078432,0.0006463724,0.0009569894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00068234,"about_ca_system_score_gemma":0.0006045889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531936,"about_ca_topic_score_gemma":0.001063974,"domain_scores_codex":[0.9996542,0.0000539773,0.00002118237,0.00004876298,0.0001266357,0.0000952492],"domain_scores_gemma":[0.999846,0.00002601303,0.00003227952,0.00002014584,0.00003665599,0.00003878467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001971623,0.00005669821,0.0007432582,0.0001232798,0.00002294713,0.0004092176,0.00004507994,0.00006698481,0.984171,0.001224488,0.0006329116,0.01230689],"study_design_scores_gemma":[0.00005064297,0.0004696705,0.009554088,0.00002501442,0.00002156536,0.001744299,0.00004381956,0.001171913,0.9711937,0.001372572,0.01433628,0.00001649609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9189084,0.02484756,0.02770978,0.001105987,0.000598685,0.0003386704,0.0005208345,0.000785653,0.02518451],"genre_scores_gemma":[0.9807042,0.004010646,0.007735567,0.0002902558,0.00007663405,0.00004681683,0.0002054375,0.00002167063,0.006908685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002974062,"threshold_uncertainty_score":0.009949207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03733437031904928,"score_gpt":0.3112886793221463,"score_spread":0.273954309003097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}