{"id":"W2771548075","doi":"10.1016/j.ahj.2017.12.001","title":"A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial","year":2017,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute; McMaster University; Population Health Research Institute","funders":"","keywords":"Medicine; Atrial fibrillation; Atrial flutter; Internal medicine; Cardiology; Metoprolol; Heart failure; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005266867,0.003193126,0.004349996,0.0005429374,0.0007215569,0.001706317,0.001566675,0.00363345,0.004194539],"category_scores_gemma":[0.007010873,0.001042329,0.003314768,0.00054774,0.002350258,0.002150236,0.0008149058,0.00440464,0.0009696892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007504133,"about_ca_system_score_gemma":0.000983387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000667165,"about_ca_topic_score_gemma":0.001256115,"domain_scores_codex":[0.9950981,0.003402037,0.0003474336,0.000575743,0.0002118933,0.0003647958],"domain_scores_gemma":[0.9975061,0.0009589733,0.000469687,0.0003176649,0.0001480906,0.0005994958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9899789,0.001584217,0.000759131,0.0002638909,0.001982237,0.00004742103,0.0000447852,0.0002572268,0.001160459,0.0003410751,0.000139937,0.003440624],"study_design_scores_gemma":[0.9680861,0.02696448,0.00164999,0.00002700127,0.001743697,0.00004252481,0.00002358134,0.0003388484,0.0002187622,0.000527746,0.0003506609,0.00002664494],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9773899,0.005801835,0.001922955,0.0021794,0.001183136,0.006766492,0.001069206,0.0000895089,0.003597604],"genre_scores_gemma":[0.9874393,0.00130695,0.002766133,0.001847609,0.0008286522,0.003823109,0.0006937442,0.0000218133,0.001272584],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.005266867,"threshold_uncertainty_score":0.02785414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01877766980074036,"score_gpt":0.2987482590347168,"score_spread":0.2799705892339764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}