{"id":"W2771706601","doi":"10.1093/annonc/mdx711.077","title":"Phase 3 KEYNOTE-412 trial: Pembrolizumab plus chemoradiation (CRT) vs CRT alone for locally advanced head and neck squamous cell carcinoma (LA-HNSCC)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Medicine; Head and neck squamous-cell carcinoma; Internal medicine; Placebo; Oncology; Head and neck cancer; Regimen; Phases of clinical research; Response Evaluation Criteria in Solid Tumors; Chemoradiotherapy; Urology; Cancer; Surgery; Clinical trial; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001410986,0.001638559,0.00217445,0.0003286478,0.0004821201,0.00133903,0.001171922,0.001479174,0.0103554],"category_scores_gemma":[0.001076279,0.0005377213,0.002568759,0.0003502601,0.0008169065,0.001290785,0.0004962712,0.004867535,0.002023713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00158156,"about_ca_system_score_gemma":0.00147179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002083387,"about_ca_topic_score_gemma":0.005135914,"domain_scores_codex":[0.999718,0.0001103299,0.0000107636,0.00006552909,0.00002331348,0.00007200629],"domain_scores_gemma":[0.9996111,0.00009822615,0.00006651354,0.0000321251,0.00002707011,0.0001650115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9053167,0.009684484,0.0009389857,0.00220418,0.002196603,0.0001125595,0.0001799227,0.002397139,0.008947629,0.0006521076,0.008409925,0.05895969],"study_design_scores_gemma":[0.9185342,0.07200997,0.002942265,0.0001099023,0.0009271982,0.00009471095,0.00008106266,0.001064793,0.0008011462,0.000621095,0.002783551,0.000030036],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663939,0.008643182,0.001114305,0.002778003,0.001587916,0.004773246,0.005246601,0.0004146379,0.009048077],"genre_scores_gemma":[0.9638328,0.004191386,0.002823175,0.003482036,0.0005664853,0.005437894,0.004858909,0.0001160655,0.01469126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0103554,"threshold_uncertainty_score":0.03464228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06854208842948625,"score_gpt":0.4002969800796791,"score_spread":0.3317548916501929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}