{"id":"W2772067948","doi":"10.1038/nrd.2017.221","title":"Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome","year":2017,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":346,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"NIH Clinical Center; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Intellectual and Developmental Disabilities Research Center; Health Resources and Services Administration; FRAXA Research Foundation; Hospices Civils de Lyon; Institut National de la Santé et de la Recherche Médicale; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense; European Commission; European Federation of Pharmaceutical Industries and Associations; Autism Speaks; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; Odense Universitetshospital; National Science Foundation","keywords":"Fragile X syndrome; Autism; Neurodevelopmental disorder; Clinical trial; Drug development; Intellectual disability; Medicine; Autism spectrum disorder; Neuroscience; Metabotropic glutamate receptor 5; Rett syndrome; Metabotropic glutamate receptor; Psychiatry; Psychology; Drug; Agonist; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0006066319,0.001405763,0.002688895,0.0001776809,0.0006126317,0.0003825157,0.001855927,0.0009628707,0.00003328306],"category_scores_gemma":[0.0003499468,0.001180451,0.001462927,0.0001706141,0.0001484944,0.0000354134,0.0009708921,0.001060664,0.0001412474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001144879,"about_ca_system_score_gemma":0.00116903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001408637,"about_ca_topic_score_gemma":0.0002775943,"domain_scores_codex":[0.9948409,0.000312388,0.001418246,0.002159209,0.0004240402,0.0008452275],"domain_scores_gemma":[0.9967952,0.00009490795,0.001198801,0.001613754,0.00006242423,0.0002348535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001976071,0.0001723177,0.000009574092,0.005434962,0.0003612362,0.000008396057,0.00005549565,0.000001023109,0.00005305465,0.00001867322,0.02630368,0.9675618],"study_design_scores_gemma":[0.0004679433,0.00003598403,0.0001387694,0.005397513,0.0003916723,0.00001661885,0.0000189262,5.336253e-7,0.00007809969,0.0001077277,0.9919413,0.0014049],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004858569,0.9928186,0.0001096878,0.0002514179,0.001605485,0.003391053,0.0008222198,0.00003042374,0.000485256],"genre_scores_gemma":[0.0003230041,0.9788523,0.002095083,0.0003763571,0.0001630167,0.001407214,0.009280464,0.0002717109,0.007230854],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.966157,"threshold_uncertainty_score":0.9998693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06292734044619243,"score_gpt":0.3542284495376041,"score_spread":0.2913011090914117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}