{"id":"W2772067948","doi":"10.1038/nrd.2017.221","title":"Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome","year":2017,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":346,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"NIH Clinical Center; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Intellectual and Developmental Disabilities Research Center; Health Resources and Services Administration; FRAXA Research Foundation; Hospices Civils de Lyon; Institut National de la Santé et de la Recherche Médicale; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense; European Commission; European Federation of Pharmaceutical Industries and Associations; Autism Speaks; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; Odense Universitetshospital; National Science Foundation","keywords":"Fragile X syndrome; Autism; Neurodevelopmental disorder; Clinical trial; Drug development; Intellectual disability; Medicine; Autism spectrum disorder; Neuroscience; Metabotropic glutamate receptor 5; Rett syndrome; Metabotropic glutamate receptor; Psychiatry; Psychology; Drug; Agonist; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001314477,0.00100266,0.001758217,0.001684311,0.000303431,0.001228503,0.001077953,0.001688318,0.002895844],"category_scores_gemma":[0.00157123,0.000292184,0.0006551932,0.001564173,0.0011006,0.001899768,0.001183049,0.003486634,0.001172128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047667,"about_ca_system_score_gemma":0.001445209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001420814,"about_ca_topic_score_gemma":0.003742086,"domain_scores_codex":[0.9997002,0.00006420561,0.00003338703,0.00005472567,0.0001092886,0.000038305],"domain_scores_gemma":[0.9990774,0.000575142,0.00006576566,0.0000236035,0.0001756793,0.00008233184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001293578,0.00006979662,0.0002546154,0.009485023,0.0001612022,0.0004545093,0.00006805077,0.0008241253,0.001935191,0.01270765,0.0619294,0.911981],"study_design_scores_gemma":[0.00005440187,0.00009257407,0.0003489227,0.002222713,0.0001256606,0.001183313,0.00004988394,0.0001938737,0.0005275977,0.006256662,0.9889237,0.00002059034],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001144616,0.9975697,0.0003390771,0.001020362,0.000244525,0.000003424673,0.00002174536,0.00001177024,0.000674847],"genre_scores_gemma":[0.0008646708,0.9975207,0.0003116869,0.000622077,0.0002110328,0.000005176566,0.00002640073,0.000002477354,0.000435628],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002895844,"threshold_uncertainty_score":0.009687543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06292734044619243,"score_gpt":0.3542284495376041,"score_spread":0.2913011090914117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}