{"id":"W2772124511","doi":"10.1021/acs.biomac.7b01297","title":"siRNA Delivery with Chitosan: Influence of Chitosan Molecular Weight, Degree of Deacetylation, and Amine to Phosphate Ratio on in Vitro Silencing Efficiency, Hemocompatibility, Biodistribution, and in Vivo Efficacy","year":2017,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Canadian Institutes of Health Research","keywords":"Biodistribution; In vivo; Gene knockdown; Chitosan; Chemistry; Transfection; In vitro; Genotoxicity; Biophysics; Biochemistry; Biology; Organic chemistry; Toxicity; Biotechnology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003343267,0.0005039882,0.0002204468,0.0002030807,0.000114705,0.0002548348,0.0001906282,0.0002431232,0.0005504789],"category_scores_gemma":[0.0003407116,0.0001795989,0.0002120204,0.0001942033,0.0002223703,0.000229621,0.0001286244,0.0002274941,0.0001223759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005392416,"about_ca_system_score_gemma":0.0003784165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002239089,"about_ca_topic_score_gemma":0.003174706,"domain_scores_codex":[0.999821,0.00003844894,0.00002901185,0.00003550815,0.00003973987,0.00003641738],"domain_scores_gemma":[0.9998016,0.00006092308,0.00006222157,0.00001172089,0.00003147791,0.00003213594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001092457,0.00001448343,0.00006617499,0.00002442624,0.000004838048,0.0000134146,0.000006648987,0.00007237744,0.9990938,0.000009275027,0.000008780581,0.0005765507],"study_design_scores_gemma":[0.000005533081,0.0001916313,0.0006080921,0.000001659215,0.00001204325,0.00002157004,0.00000267255,0.0002987311,0.9986984,0.000003769755,0.0001532738,0.000002715149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957343,0.001431616,0.001872248,0.00005526535,0.00001317003,0.00003867744,0.0001263628,0.00003464868,0.0006938208],"genre_scores_gemma":[0.9950433,0.001044791,0.002521529,0.00003885357,0.000006792489,0.00003397456,0.0001745779,0.00002317969,0.001113073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002239089,"threshold_uncertainty_score":0.004452169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019445230646116,"score_gpt":0.2458013347864558,"score_spread":0.2356068824799946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}