{"id":"W2772124511","doi":"10.1021/acs.biomac.7b01297","title":"siRNA Delivery with Chitosan: Influence of Chitosan Molecular Weight, Degree of Deacetylation, and Amine to Phosphate Ratio on in Vitro Silencing Efficiency, Hemocompatibility, Biodistribution, and in Vivo Efficacy","year":2017,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Canadian Institutes of Health Research","keywords":"Biodistribution; In vivo; Gene knockdown; Chitosan; Chemistry; Transfection; In vitro; Genotoxicity; Biophysics; Biochemistry; Biology; Organic chemistry; Toxicity; Biotechnology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001165156,0.0002156498,0.000291811,0.0001397021,0.00008395037,0.00003577812,0.0002664519,0.0001061139,0.00000100361],"category_scores_gemma":[0.000158997,0.0001931537,0.00003877041,0.0001430313,0.0002786301,0.00001717282,0.0001838281,0.00006277391,2.983246e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007950532,"about_ca_system_score_gemma":0.00006449441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003357087,"about_ca_topic_score_gemma":0.0001667309,"domain_scores_codex":[0.9986862,0.0000560433,0.0003892163,0.000476851,0.0001638037,0.0002278978],"domain_scores_gemma":[0.9991068,0.00002377684,0.0002308035,0.0004903242,0.00006500577,0.00008334581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006339235,0.0001429606,0.03324319,0.00004484289,0.00002160014,0.00001346013,0.00009619723,0.0003731198,0.9640628,0.00002495828,0.000002039851,0.001340977],"study_design_scores_gemma":[0.0008321818,0.0004515353,0.275893,0.0001265948,0.000009394429,0.000006069848,0.00002669721,0.0001256355,0.7223663,0.000008172298,0.000002290764,0.0001521809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983238,0.0004722514,0.0005795236,0.00008722757,0.00002159014,0.0003535815,0.00007964885,0.00000449654,0.00007786055],"genre_scores_gemma":[0.9991241,0.0001000578,0.0006597482,0.00004575934,0.00001265043,0.00001286391,0.00003179271,0.00001169537,0.000001353511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2426498,"threshold_uncertainty_score":0.7876581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019445230646116,"score_gpt":0.2458013347864558,"score_spread":0.2356068824799946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}