{"id":"W2772259112","doi":"10.1016/s1470-2045(17)30856-2","title":"Go, no-go decision making for phase 3 clinical trials: ACT IV revisited – Authors' reply","year":2017,"lang":"en","type":"letter","venue":"The Lancet Oncology","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Foothills Medical Centre; University of Calgary; Sunnybrook Health Science Centre; Juravinski Cancer Centre","funders":"Novartis; Actelion Pharmaceuticals; Roche; Merck; Bristol-Myers Squibb","keywords":"Go/no go; Phase (matter); Clinical decision making; Medicine; Psychology; Intensive care medicine; Economics; Operations management; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04044344,0.0009014609,0.003318385,0.001379418,0.006817375,0.009642532,0.005446319,0.148147,0.007515676],"category_scores_gemma":[0.1841859,0.002038827,0.002705776,0.001968595,0.01462998,0.008961233,0.005088194,0.1262091,0.00689792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01025438,"about_ca_system_score_gemma":0.02034959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009701685,"about_ca_topic_score_gemma":0.01408984,"domain_scores_codex":[0.9618745,0.01754357,0.005842415,0.003745234,0.00750241,0.003491924],"domain_scores_gemma":[0.8242475,0.1395299,0.007473953,0.003578853,0.01550994,0.0096598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008938325,0.0000227764,0.0004315054,0.0001004552,0.00005029559,0.0004643367,0.0004190166,0.00008098797,0.00009467595,0.007860845,0.9852623,0.005123337],"study_design_scores_gemma":[0.0005812162,0.00009214994,0.001198046,0.001096941,0.0001706816,0.001060727,0.001160728,0.0006194185,0.0004048141,0.05183378,0.9414776,0.0003038503],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00008077814,0.0003515886,0.00005511475,0.993792,0.005277125,0.000004867932,0.00002517691,0.00000773193,0.0004056622],"genre_scores_gemma":[0.0009678557,0.0001630845,0.0001147341,0.9901731,0.008027687,0.00002251264,0.000009006547,0.00001034569,0.0005116196],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.148147,"threshold_uncertainty_score":0.2138879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8258981385330232,"score_gpt":0.7328234551869758,"score_spread":0.0930746833460474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}