{"id":"W2772285283","doi":"10.1038/s41598-017-18368-w","title":"Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University Health Network","keywords":"Diffuse large B-cell lymphoma; Lymphoma; Cancer research; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006750226,0.0002225288,0.0002284171,0.000201754,0.00008745028,0.0002184121,0.0001275442,0.0001399324,0.0008245568],"category_scores_gemma":[0.00007072076,0.00007749693,0.000094349,0.000121208,0.0001803608,0.0001112374,0.00007972857,0.0004143681,0.0001601596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002465862,"about_ca_system_score_gemma":0.0001956999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003768735,"about_ca_topic_score_gemma":0.001273662,"domain_scores_codex":[0.9999392,0.00001182817,0.000003257828,0.00001379303,0.00001658941,0.00001532988],"domain_scores_gemma":[0.9999738,0.000005153983,0.00000842432,0.000003834464,0.000001931082,0.000006897712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004061251,0.0001789013,0.000266917,0.00004663933,0.000005353111,0.00003257708,0.00001088074,0.0003750702,0.9848139,0.0001302113,0.000174715,0.01355877],"study_design_scores_gemma":[0.0000958302,0.003140002,0.002366501,0.000003751918,0.00001529846,0.0003107321,0.00001021602,0.001785402,0.9891369,0.00003981136,0.003089589,0.000005912308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903673,0.002714226,0.003228979,0.00009090737,0.00003730176,0.00007625687,0.0002167404,0.0002478638,0.003020471],"genre_scores_gemma":[0.9965008,0.0007170215,0.00149361,0.00002511569,0.000008866758,0.00003306411,0.0001765805,0.000008624952,0.001036178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008245568,"threshold_uncertainty_score":0.002758443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02998512444760973,"score_gpt":0.3446735862666426,"score_spread":0.3146884618190329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}