{"id":"W2772300373","doi":"10.1016/j.tibs.2017.11.001","title":"The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation","year":2017,"lang":"en","type":"review","venue":"Trends in Biochemical Sciences","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; University of Toronto","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Institut de Recherche Clinique De Montréal; Ligue Contre le Cancer; Agence Nationale de la Recherche; CNIB","keywords":"Protein quaternary structure; Quaternary; Chaperone (clinical); Chemistry; Computational biology; Biology; Paleontology; Biochemistry; Protein subunit; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007900793,0.0003164974,0.0005926308,0.0001791539,0.0007860248,0.0004284912,0.001418258,0.0003106292,0.0001125812],"category_scores_gemma":[0.0001268279,0.0001651356,0.0001831129,0.0003251078,0.0007035627,0.0004050248,0.00008114123,0.0001997038,0.000009607918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000087426,"about_ca_system_score_gemma":0.0001116631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003011068,"about_ca_topic_score_gemma":0.0001072118,"domain_scores_codex":[0.9979261,0.0001056838,0.0005174726,0.000586667,0.000389434,0.0004746137],"domain_scores_gemma":[0.9986469,0.0002150698,0.0004973452,0.0005163902,0.00003632679,0.00008799729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001654592,0.00001583723,0.000003539847,0.0005848233,0.000003061234,7.061849e-7,0.0000326473,0.000003305649,0.003207136,0.0003590311,0.0008188157,0.9949545],"study_design_scores_gemma":[0.0002844884,0.0002718443,0.00001954968,0.001224902,0.00008843988,0.00001639386,0.00002340752,0.0005684643,0.008232757,0.001465088,0.9873052,0.0004995016],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00242962,0.9944441,0.0001027838,0.00017827,0.00149292,0.0004391126,0.0002260842,0.00006645046,0.0006206672],"genre_scores_gemma":[0.01898864,0.9743584,0.003269129,0.000119528,0.001560644,0.0003560713,0.0007708881,0.00005149339,0.00052516],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.994455,"threshold_uncertainty_score":0.6734035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1473180292218993,"score_gpt":0.4176197122244056,"score_spread":0.2703016830025063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}