{"id":"W2772305927","doi":"10.1371/journal.pone.0188817","title":"Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Fundação para a Ciência e a Tecnologia; Wilfrid Laurier University; Department of Physical Therapy, Western Michigan University","keywords":"Biology; Mitochondrion; Biochemistry; Cell culture; Oxidative phosphorylation; Cancer cell; Oxidative stress; Cell biology; Glutathione; Cancer; Enzyme; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123026,0.0003146749,0.0002080493,0.0002809514,0.0001656171,0.0001293149,0.0001182375,0.0002149468,0.000860448],"category_scores_gemma":[0.0001850384,0.0000702179,0.0002236589,0.0002889376,0.0001412407,0.0001263816,0.000159983,0.000232378,0.0001924296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001555549,"about_ca_system_score_gemma":0.0001359082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009845443,"about_ca_topic_score_gemma":0.001203351,"domain_scores_codex":[0.9999088,0.00001914842,0.000008589614,0.00001736087,0.00003285148,0.00001322077],"domain_scores_gemma":[0.9998999,0.00002132599,0.0000210456,0.00001400614,0.00002948586,0.00001430471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001993029,0.00003147181,0.001162628,0.0000999113,0.000008459673,0.0001075647,0.00003467259,0.0001252189,0.9956234,0.00002084706,0.00002184824,0.002564716],"study_design_scores_gemma":[0.00001020159,0.001324443,0.01877858,0.000008498661,0.00002435292,0.0005429524,0.00007581258,0.0005424059,0.9768547,0.00002797236,0.001802539,0.000007416539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989872,0.006217379,0.002147773,0.00005341781,0.00002448731,0.00004035643,0.0005848295,0.00003401212,0.001025701],"genre_scores_gemma":[0.9908908,0.003762118,0.002869572,0.0000323237,0.000009374645,0.00005327418,0.001143085,0.000005334899,0.001234207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009845443,"threshold_uncertainty_score":0.002878487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0340582772285106,"score_gpt":0.2758932454024439,"score_spread":0.2418349681739333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}