{"id":"W2772306649","doi":"10.1039/c7nr08360b","title":"Technical challenges of working with extracellular vesicles","year":2017,"lang":"en","type":"review","venue":"Nanoscale","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":517,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Ministero della Salute; Ciência sem Fronteiras; Fundação de Amparo à Pesquisa do Estado de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Medical Research Council; British Council; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Newton Fund","keywords":"Extracellular vesicles; Vesicle; Nanotechnology; Extracellular; Biophysics; Materials science; Chemistry; Cell biology; Biology; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001866378,0.0007353061,0.001119733,0.001250741,0.0006317195,0.002315178,0.001056903,0.002116147,0.002946439],"category_scores_gemma":[0.001957914,0.0003841309,0.0007385482,0.0008760977,0.001051937,0.003364369,0.001570339,0.003051255,0.003030989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007130951,"about_ca_system_score_gemma":0.00140046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008894416,"about_ca_topic_score_gemma":0.0007910109,"domain_scores_codex":[0.9990786,0.0001686637,0.0001117564,0.0001281591,0.0004415483,0.00007133421],"domain_scores_gemma":[0.9990417,0.0005684742,0.00007256588,0.00004543547,0.0002278639,0.00004396187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004642812,0.00004917667,0.0002695249,0.01747415,0.00008143517,0.0006391204,0.0004140736,0.0006440557,0.01015351,0.03268181,0.03805548,0.8994913],"study_design_scores_gemma":[0.000003694889,0.00003173703,0.0001720246,0.001856095,0.00003008696,0.001542995,0.0001457433,0.0001089651,0.002360871,0.005578121,0.9881463,0.00002340734],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003159901,0.9921495,0.001763593,0.001599647,0.0008237748,0.000008838503,0.0000197735,0.00002429241,0.003294643],"genre_scores_gemma":[0.001998373,0.9924586,0.001955773,0.0008113279,0.0005319712,0.00002596385,0.00004789472,0.00001087031,0.002159141],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002946439,"threshold_uncertainty_score":0.009870529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08703357719759595,"score_gpt":0.3213941859249497,"score_spread":0.2343606087273538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}