{"id":"W2772351506","doi":"10.1097/00007890-201407151-03017","title":"Clinical and Genetic Determinants of Tacrolimus Dose During Induction and Stable Phase of Therapy.","year":2014,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Tacrolimus; Calcineurin; Medicine; CYP3A5; Dosing; Trough level; Pharmacology; CYP3A; Internal medicine; Transplantation; Urology; Genotype; Biology; Metabolism; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003781051,0.0001475529,0.0002587139,0.0003079333,0.0001721254,0.0004031348,0.0001924356,0.0003440933,0.001197796],"category_scores_gemma":[0.002405814,0.00008549777,0.0003436925,0.0006008515,0.0002074613,0.0002120454,0.0001342783,0.0004574954,0.0002295943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002992244,"about_ca_system_score_gemma":0.0002030218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005042432,"about_ca_topic_score_gemma":0.0005626329,"domain_scores_codex":[0.999557,0.00009787915,0.00006660731,0.0001026774,0.0001036009,0.00007233259],"domain_scores_gemma":[0.9969869,0.0009058068,0.001520286,0.00009732342,0.0001096977,0.0003799266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008181233,0.00005867673,0.9933467,0.00001029603,0.00004614805,0.0001506188,0.00002785307,0.00009381578,0.001382556,0.00002124675,0.0000564742,0.003987513],"study_design_scores_gemma":[0.00000785216,0.0002550969,0.9985427,0.000002084274,0.00002244867,0.0005919326,0.00001596803,0.0001751506,0.0002654565,0.00001566197,0.0001037911,0.000001929978],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987016,0.0005761755,0.0001237687,0.00002201516,0.000004387477,0.000007905024,0.0001170894,0.000004746537,0.000442303],"genre_scores_gemma":[0.9996842,0.00005124648,0.00006374213,0.00001077319,0.000006301486,0.000003928393,0.000105639,0.000001810265,0.00007229691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001197796,"threshold_uncertainty_score":0.004006982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04503352298595979,"score_gpt":0.3683575009145744,"score_spread":0.3233239779286146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}