{"id":"W2772388781","doi":"10.1073/pnas.1708215114","title":"Gα <sub>s</sub> protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Endosome; Cell biology; Ubiquitin; Epidermal growth factor receptor; Signal transduction; Biology; Vacuolar protein sorting; Signal transducing adaptor protein; Protein targeting; Ubiquitin ligase; Epidermal growth factor; Receptor; Biochemistry; Membrane protein; Gene; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005272905,0.0002864799,0.0001182208,0.0001540032,0.0001528208,0.0002577937,0.0001373485,0.0001992469,0.001152094],"category_scores_gemma":[0.00005772636,0.00009442354,0.0002227944,0.0001179175,0.0003208778,0.0001430141,0.0001970576,0.0002266644,0.0006544424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006327692,"about_ca_system_score_gemma":0.0002110305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009069917,"about_ca_topic_score_gemma":0.001339515,"domain_scores_codex":[0.9999483,0.00001002208,0.000003024559,0.00001090354,0.000009749187,0.00001806094],"domain_scores_gemma":[0.9999671,0.000003654034,0.000008224973,0.000005197989,0.000003699901,0.0000121131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001434485,0.00001104268,0.0005754631,0.00002392057,0.000006225966,0.00009646732,0.000009405753,0.0001165751,0.9968201,0.0004757505,0.0001446372,0.001577086],"study_design_scores_gemma":[0.0000152753,0.00009367711,0.009715166,0.000008386833,0.00001246142,0.0003923908,0.00006287786,0.001641058,0.9836106,0.0002373606,0.004206697,0.000004083314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993775,0.001505179,0.002021587,0.0002386549,0.00003960638,0.000009332458,0.0001361508,0.0001027968,0.002171737],"genre_scores_gemma":[0.9957332,0.0005831739,0.001046213,0.00009496242,0.000006144273,0.000005627965,0.0001772853,0.00001262347,0.002340802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152094,"threshold_uncertainty_score":0.004591048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02779138425033833,"score_gpt":0.2734442503515833,"score_spread":0.245652866101245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}