{"id":"W2772413986","doi":"10.1016/j.tins.2017.11.006","title":"Translational Control Mechanisms in Persistent Pain","year":2017,"lang":"en","type":"review","venue":"Trends in Neurosciences","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"AMPK; Neuroscience; PI3K/AKT/mTOR pathway; Nociception; Sensitization; Signal transduction; Biology; Chronic pain; Gene expression; Translation (biology); Protein kinase A; Cell biology; Medicine; Kinase; Messenger RNA; Gene; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009126815,0.0009553537,0.001272623,0.001034945,0.0003146962,0.00144778,0.00110965,0.00153026,0.003176497],"category_scores_gemma":[0.000679876,0.0002886015,0.0003867096,0.001154728,0.00128427,0.002006899,0.001225263,0.002629672,0.00155831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007589849,"about_ca_system_score_gemma":0.001415255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004757525,"about_ca_topic_score_gemma":0.0008078954,"domain_scores_codex":[0.9998342,0.00002260563,0.00002531045,0.00003614706,0.00004810092,0.00003365616],"domain_scores_gemma":[0.9997709,0.00009475718,0.0000354755,0.00001209699,0.00005461109,0.00003209682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002125443,0.00006816187,0.0002121419,0.0121509,0.00008278857,0.0005383205,0.0001133538,0.00070232,0.007408554,0.02578017,0.03991213,0.9128187],"study_design_scores_gemma":[0.00003090224,0.00006794094,0.000549159,0.002001639,0.0001080376,0.0007676008,0.00008667861,0.0002292753,0.001599963,0.01659876,0.9779337,0.00002623654],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002073996,0.9966,0.0006123736,0.0008329917,0.0007455134,0.000004494887,0.00002368096,0.00002096535,0.0009525747],"genre_scores_gemma":[0.001535594,0.9962875,0.0003425971,0.0004474161,0.0006254861,0.000008267608,0.00004579354,0.000003564396,0.0007037903],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003176497,"threshold_uncertainty_score":0.01062649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09853267776677649,"score_gpt":0.3556649260787437,"score_spread":0.2571322483119672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}