{"id":"W2772413986","doi":"10.1016/j.tins.2017.11.006","title":"Translational Control Mechanisms in Persistent Pain","year":2017,"lang":"en","type":"review","venue":"Trends in Neurosciences","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"AMPK; Neuroscience; PI3K/AKT/mTOR pathway; Nociception; Sensitization; Signal transduction; Biology; Chronic pain; Gene expression; Translation (biology); Protein kinase A; Cell biology; Medicine; Kinase; Messenger RNA; Gene; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006946402,0.0001877659,0.0003820999,0.0003336788,0.0000851618,0.00004771838,0.0003041811,0.0001976802,0.00003457823],"category_scores_gemma":[0.00009922741,0.0001544354,0.0002759062,0.0002016275,0.0001002733,0.000006302116,0.00002252587,0.0001241446,0.000002966236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001440702,"about_ca_system_score_gemma":0.00008762401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006429292,"about_ca_topic_score_gemma":0.00006256704,"domain_scores_codex":[0.9985787,0.0002644369,0.000306737,0.0004655992,0.0001855521,0.0001989733],"domain_scores_gemma":[0.9995359,0.00002621227,0.0001628322,0.0002195627,0.00001350088,0.00004194613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009029774,0.00004687195,0.00002719808,0.0001374766,0.00000500493,0.000004538926,0.00001139862,0.0001725723,0.00007159176,0.0001235305,0.000137475,0.9992533],"study_design_scores_gemma":[0.0003552943,0.0002340239,0.0001356316,0.0003264319,0.00002352412,0.00001335167,0.00001001802,0.001482471,0.000006190664,0.00004567091,0.9971473,0.0002200575],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003365528,0.9941536,0.001373752,0.0001735494,0.002315199,0.0002562671,0.00004665582,0.00001031058,0.001636963],"genre_scores_gemma":[0.01211575,0.9831582,0.00005629973,0.0001227507,0.0002383154,0.00007791589,0.0001764131,0.00001867089,0.004035677],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9990333,"threshold_uncertainty_score":0.6297695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09853267776677649,"score_gpt":0.3556649260787437,"score_spread":0.2571322483119672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}