{"id":"W2772419818","doi":"10.1097/00007890-201407151-02306","title":"Prolong Allograft Survival by Silencing mTOR Gene Using Mannose Liposome in Heart Transplantation.","year":2014,"lang":"en","type":"article","venue":"Transplantation","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Gene silencing; Transplantation; PI3K/AKT/mTOR pathway; Medicine; Discovery and development of mTOR inhibitors; Mannose; Heart transplantation; Immunology; Cancer research; Gene; Biology; Internal medicine; Cell biology; Signal transduction; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039709,0.0003751057,0.0001949796,0.0001385385,0.0001082679,0.0001580456,0.0001185821,0.0002527148,0.000609325],"category_scores_gemma":[0.00004917723,0.000076995,0.0002361288,0.00006288398,0.0001482976,0.0002116996,0.0001591963,0.0003923865,0.0001395924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001699103,"about_ca_system_score_gemma":0.0001467035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001804792,"about_ca_topic_score_gemma":0.0002583656,"domain_scores_codex":[0.9999437,0.000007955357,0.000005077217,0.00001187702,0.00001574924,0.00001558719],"domain_scores_gemma":[0.9999688,0.000003430343,0.00001249161,0.000002052413,0.00000375691,0.000009397218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002468687,0.00008022408,0.0001417212,0.00006896937,0.000007299426,0.00003687804,0.000008306462,0.0001426155,0.9964398,0.0001027868,0.00008100826,0.002643672],"study_design_scores_gemma":[0.00005144001,0.001581665,0.001656481,0.000006912745,0.00003835515,0.0001975278,0.00001157006,0.001252306,0.9933913,0.00005192293,0.001754585,0.000006053619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990922,0.002851317,0.004561095,0.0001512599,0.00007858313,0.00006287819,0.0001699028,0.0001069392,0.001096034],"genre_scores_gemma":[0.9942449,0.001248626,0.002390734,0.00006565153,0.0000192044,0.00007540076,0.0002203385,0.00001355817,0.001721705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000609325,"threshold_uncertainty_score":0.002038419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009528032832858024,"score_gpt":0.2635740216037415,"score_spread":0.2540459887708835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}