{"id":"W2772434918","doi":"10.1038/s41419-017-0050-3","title":"Pyridoxine 5′-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer","year":2017,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"National Natural Science Foundation of China; Science and Technology Commission of Shanghai Municipality; Natural Science Foundation of Shanghai","keywords":"Gene knockdown; Cancer research; Cell growth; Carcinogenesis; Internal medicine; Endocrinology; Medicine; Chemistry; Apoptosis; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303908,0.0002180532,0.0001471369,0.000021489,0.0003543163,0.000146197,0.0002440121,0.0000892444,0.00003950287],"category_scores_gemma":[0.0000666031,0.0001642744,0.00005852067,0.00002803449,0.0001693534,0.0000115215,0.0001293955,0.00008351488,0.000001691732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009193735,"about_ca_system_score_gemma":0.0001758103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001765782,"about_ca_topic_score_gemma":0.00001364368,"domain_scores_codex":[0.9989283,0.0000364834,0.0001775478,0.0004462274,0.0001155692,0.0002958542],"domain_scores_gemma":[0.9989887,0.00001777357,0.000116287,0.0004638568,0.00003064319,0.000382745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008902649,0.0002960603,0.03557269,0.0001006853,0.00006680442,0.00002753508,0.000156427,0.0001746884,0.9588553,0.00005876164,0.0008458227,0.002954913],"study_design_scores_gemma":[0.005947882,0.0001496481,0.122036,0.0001386114,0.0001723607,0.000003895027,0.00005914799,0.005536031,0.8288203,0.0009963317,0.03527789,0.0008619798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724022,0.02564764,0.0003867358,0.0007005954,0.00007471941,0.000261547,0.0004319514,0.00001210158,0.00008252007],"genre_scores_gemma":[0.9973854,0.0003901539,0.00007266306,0.00128807,0.0001259342,0.00005271665,0.00009457402,0.00002880656,0.0005616295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1300351,"threshold_uncertainty_score":0.6698915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236181881270915,"score_gpt":0.2418467899274105,"score_spread":0.2294849711147014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}