{"id":"W2772446956","doi":"","title":"Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.","year":2017,"lang":"en","type":"article","venue":"DSpace@MIT (Massachusetts Institute of Technology)","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Camptothecin; Topoisomerase; Proteasome; Ubiquitin; Degradation (telecommunications); Resistance (ecology); Cell biology; Biochemistry; Genetics; Enzyme; Gene; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002253214,0.0002325703,0.0002836482,0.00009583392,0.0002790448,0.0000308567,0.0007673035,0.0004167655,0.00001926417],"category_scores_gemma":[0.0002175986,0.0001940111,0.0001018735,0.0001305319,0.0005718483,0.00002631026,0.0001653647,0.0001590792,0.000002547686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003776482,"about_ca_system_score_gemma":0.0001143804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000729113,"about_ca_topic_score_gemma":0.000297207,"domain_scores_codex":[0.9986749,0.00002799651,0.0003774764,0.0004086499,0.0002428805,0.0002681499],"domain_scores_gemma":[0.9976972,0.000008896003,0.0007339671,0.001331006,0.0001803249,0.00004861226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106811,0.00006876871,0.0003725762,0.00003437291,0.00009379999,8.778209e-7,0.00004102072,0.00000133082,0.9803931,0.0008339163,0.006110965,0.01193866],"study_design_scores_gemma":[0.0007090903,0.0001373701,0.0001519049,0.00004611297,0.00002710131,0.000003309788,0.00002955957,0.00002864217,0.7410275,0.0006015932,0.2570782,0.0001595583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819385,0.002254736,0.003667348,0.009449741,0.0003033432,0.0008602752,0.0008465938,0.00005125607,0.0006281438],"genre_scores_gemma":[0.9943064,0.0003478835,0.001881965,0.0001846027,0.00004322773,0.0001022884,0.0002092002,0.00003006158,0.002894362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2509673,"threshold_uncertainty_score":0.7911543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076463603384638,"score_gpt":0.243424749784064,"score_spread":0.2326601137502176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}