{"id":"W2772446956","doi":"","title":"Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.","year":2017,"lang":"en","type":"article","venue":"DSpace@MIT (Massachusetts Institute of Technology)","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Camptothecin; Topoisomerase; Proteasome; Ubiquitin; Degradation (telecommunications); Resistance (ecology); Cell biology; Biochemistry; Genetics; Enzyme; Gene; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007514237,0.0002906756,0.0001799484,0.0002832702,0.0002123811,0.0003090889,0.0001324363,0.0001885463,0.001892341],"category_scores_gemma":[0.0001154623,0.000114291,0.0001223771,0.0001660287,0.0002241659,0.0001615618,0.000135569,0.0003694764,0.0005387217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007020597,"about_ca_system_score_gemma":0.0002963123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026043,"about_ca_topic_score_gemma":0.001411673,"domain_scores_codex":[0.9998775,0.0000112453,0.000006956659,0.00003138246,0.00004991033,0.0000230446],"domain_scores_gemma":[0.9998996,0.00001034817,0.00003895798,0.0000107192,0.00001655405,0.00002369296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006668233,0.00002109828,0.0004808578,0.00003935409,0.000005325215,0.00007649725,0.000008818237,0.00006037187,0.9951865,0.0001692031,0.0002048004,0.003680505],"study_design_scores_gemma":[0.00001327413,0.0002274002,0.01542722,0.00000977217,0.000009891784,0.0007686173,0.00002574292,0.0006081406,0.9750664,0.0001524362,0.00768437,0.000006795192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603952,0.02089447,0.004807235,0.000566124,0.0001198436,0.0001403618,0.001640941,0.0005415856,0.01089423],"genre_scores_gemma":[0.9861124,0.005623638,0.0014672,0.00008542786,0.00002900874,0.00004379202,0.0007981037,0.00002271729,0.005817704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892341,"threshold_uncertainty_score":0.00633049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076463603384638,"score_gpt":0.243424749784064,"score_spread":0.2326601137502176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}