{"id":"W2772502272","doi":"10.1016/j.scr.2017.12.010","title":"Lymphoblastoids cell lines – Derived iPSC line from a 26-year-old myotonic dystrophy type 1 patient carrying (CTG) 200 expansion in the DMPK gene: CHUQi001-A","year":2017,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; Sendai virus; Induced pluripotent stem cell; KLF4; Myotonic dystrophy; SOX2; Mutation; Germ layer; Karyotype; Somatic cell; Cell culture; Trinucleotide repeat expansion; Molecular biology; Genetics; Virology; Gene; Chromosome; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001359396,0.0003114375,0.0002416792,0.0004440372,0.0003134664,0.0001991881,0.0001737475,0.000287033,0.005549343],"category_scores_gemma":[0.0001539018,0.0001178461,0.000180464,0.0003358043,0.0001820589,0.0001137729,0.0002287423,0.0006304655,0.002178486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209394,"about_ca_system_score_gemma":0.0002535068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170437,"about_ca_topic_score_gemma":0.001467502,"domain_scores_codex":[0.9999112,0.000009888691,0.0000150911,0.00002415579,0.00002366065,0.0000159622],"domain_scores_gemma":[0.9999187,0.00001797912,0.00001139103,0.00001402327,0.00001314586,0.00002473726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001851649,0.00005492831,0.002651411,0.00005377957,0.000008008925,0.0024974,0.0001755091,0.00006436081,0.9898807,0.0003381887,0.0005382987,0.003552328],"study_design_scores_gemma":[0.000152633,0.0006780057,0.04258893,0.00003197763,0.00009080539,0.02636093,0.0003023726,0.001084764,0.8757507,0.0003181322,0.05259598,0.00004472998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789876,0.0008554884,0.007770013,0.0002258634,0.0000898515,0.0002933269,0.005082489,0.0002392679,0.006456038],"genre_scores_gemma":[0.9612058,0.001244552,0.008302096,0.0001518129,0.00004209822,0.0003121609,0.01230488,0.00008769271,0.01634896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005549343,"threshold_uncertainty_score":0.0185644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04044103442163553,"score_gpt":0.3125638307906999,"score_spread":0.2721227963690643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}