{"id":"W2772502272","doi":"10.1016/j.scr.2017.12.010","title":"Lymphoblastoids cell lines – Derived iPSC line from a 26-year-old myotonic dystrophy type 1 patient carrying (CTG) 200 expansion in the DMPK gene: CHUQi001-A","year":2017,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; Sendai virus; Induced pluripotent stem cell; KLF4; Myotonic dystrophy; SOX2; Mutation; Germ layer; Karyotype; Somatic cell; Cell culture; Trinucleotide repeat expansion; Molecular biology; Genetics; Virology; Gene; Chromosome; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001384041,0.0003463242,0.0003289757,0.000268295,0.0008043153,0.0003481393,0.001827782,0.0003925399,0.00008092816],"category_scores_gemma":[0.0001079674,0.0002718717,0.0001574087,0.000273785,0.0003490051,0.00002127836,0.001257281,0.0007142415,0.0003856388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001528653,"about_ca_system_score_gemma":0.0005719469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009008684,"about_ca_topic_score_gemma":0.0003137919,"domain_scores_codex":[0.9952636,0.0007072568,0.0004711039,0.001011905,0.001382999,0.001163088],"domain_scores_gemma":[0.9966379,0.0001567037,0.0001705929,0.00229308,0.0004851699,0.0002565523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005587449,0.0002304226,0.002139819,0.00007908452,0.00002627456,0.0001299681,0.0004805464,0.000212577,0.9921551,0.000005104058,0.001617535,0.002364798],"study_design_scores_gemma":[0.00181778,0.00115242,0.002705552,0.00008486488,0.00001226748,0.000006988577,0.0009776949,0.0009731915,0.9776508,0.0000517573,0.01418321,0.000383525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866865,0.003208681,0.00003395036,0.000308944,0.0002205152,0.0009854321,0.00005202394,0.00001917136,0.008484816],"genre_scores_gemma":[0.9827142,0.001879743,0.0002056297,0.00006444233,0.0004142388,0.0001126459,0.000119654,0.0000938368,0.01439558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01450438,"threshold_uncertainty_score":0.9999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04044103442163553,"score_gpt":0.3125638307906999,"score_spread":0.2721227963690643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}