{"id":"W2772520665","doi":"10.3390/epigenomes1030022","title":"PRC1 Prevents Replication Stress during Chondrogenic Transit Amplification","year":2017,"lang":"en","type":"article","venue":"Epigenomes","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; European Molecular Biology Organization","keywords":"Chondrogenesis; Cell biology; Biology; DNA replication; Polycomb-group proteins; Chromatin; Transcription factor; Genetics; DNA; Stem cell; Repressor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718979,0.0001198092,0.00009917722,0.00003122912,0.0004188919,0.00008177262,0.00033133,0.0001107095,0.00002187386],"category_scores_gemma":[0.00008003209,0.0001266566,0.00007881728,0.00002433333,0.00004824046,0.000009689293,0.00006256084,0.00005148091,0.00002047219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001704159,"about_ca_system_score_gemma":0.00003043027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000282455,"about_ca_topic_score_gemma":0.00004690774,"domain_scores_codex":[0.9990249,0.00003522946,0.0002006683,0.0004409821,0.0001144318,0.0001838188],"domain_scores_gemma":[0.998305,0.00000382652,0.000202743,0.001358917,0.00006168061,0.0000678962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002310868,0.00004476043,0.03793401,0.00002207248,0.0000335511,5.580191e-7,0.00009290149,0.00006871645,0.9527558,0.00005510837,0.00002120277,0.008948233],"study_design_scores_gemma":[0.0002426605,0.0000393541,0.3006182,0.000009514975,0.00001254895,8.203796e-7,0.00001360818,0.00001209744,0.6906827,0.0002096504,0.008030456,0.0001284005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935203,0.002332942,0.002444719,0.000212065,0.0001844122,0.0002655272,0.0000276459,0.00001566807,0.0009967535],"genre_scores_gemma":[0.9953578,0.00129582,0.0005141461,0.00001138634,0.0003184284,0.00004581589,0.000223291,0.00002346911,0.002209852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2626842,"threshold_uncertainty_score":0.5164907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774175777634593,"score_gpt":0.2904081542087573,"score_spread":0.2726663964324114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}