{"id":"W2772528715","doi":"10.1089/nat.2017.0702","title":"Structural Studies and Gene Silencing Activity of siRNAs Containing Cationic Phosphoramidate Linkages","year":2017,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Phosphoramidate; Gene silencing; Cationic polymerization; Small interfering RNA; Gene; Chemistry; Biology; Transfection; Computational biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001754283,0.0002772163,0.0001553877,0.00009127162,0.0001194336,0.0001393379,0.0001686156,0.0002059334,0.0005467967],"category_scores_gemma":[0.0002318961,0.0001553487,0.0001714683,0.00008478444,0.0001729996,0.0001360708,0.00007832562,0.0002328846,0.0001913444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002563787,"about_ca_system_score_gemma":0.0001930057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000636194,"about_ca_topic_score_gemma":0.0007767818,"domain_scores_codex":[0.9999219,0.00002125907,0.000006591237,0.0000166262,0.00002223383,0.00001130598],"domain_scores_gemma":[0.9998816,0.00002948603,0.00003461626,0.000007568429,0.00002397419,0.00002272219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002561827,0.000005153036,0.00004879013,0.00001409356,0.000001617172,0.00001777176,0.000009240141,0.0001955458,0.999283,0.0000354322,0.000004449636,0.0003592625],"study_design_scores_gemma":[0.000004595617,0.0001706583,0.0004866194,0.000001240164,0.000005011263,0.00005884679,0.000004890474,0.0005745228,0.9983198,0.00001002778,0.0003612057,0.000002536271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995953,0.0003440984,0.002709,0.00002510126,0.000004748254,0.00001447478,0.00007148842,0.00002339828,0.0008547085],"genre_scores_gemma":[0.9947402,0.0003735286,0.00363009,0.00002432773,0.000002545742,0.0000215667,0.000223156,0.0000129367,0.0009718341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000636194,"threshold_uncertainty_score":0.001860142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0504872898028882,"score_gpt":0.325595727291733,"score_spread":0.2751084374888448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}