{"id":"W2772528715","doi":"10.1089/nat.2017.0702","title":"Structural Studies and Gene Silencing Activity of siRNAs Containing Cationic Phosphoramidate Linkages","year":2017,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Phosphoramidate; Gene silencing; Cationic polymerization; Small interfering RNA; Gene; Chemistry; Biology; Transfection; Computational biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077875,0.000131973,0.0001770559,0.00001743309,0.000262089,0.00004848726,0.0002280508,0.00009957615,0.000003869572],"category_scores_gemma":[0.00003689135,0.0001159012,0.00004765904,0.0000145581,0.0002354857,0.0000132873,0.0001708777,0.00008167077,0.000001530381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001123884,"about_ca_system_score_gemma":0.00003559651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000028537,"about_ca_topic_score_gemma":0.00002496411,"domain_scores_codex":[0.9993843,0.00002704047,0.0001381929,0.0002162787,0.00008178566,0.0001523544],"domain_scores_gemma":[0.9991804,0.00001109952,0.0002107897,0.0004323074,0.000135149,0.00003020047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005939272,0.000007198531,0.007350991,0.00001894642,0.000219836,0.000001120978,0.0004385553,0.000009544393,0.9710598,0.00003329286,0.000007672391,0.02079364],"study_design_scores_gemma":[0.0003162022,0.0003012336,0.04127517,0.00002576979,0.00004870544,0.000007088627,0.0003413707,0.000286517,0.9568655,0.0002488848,0.0001465051,0.0001370648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994614,0.004806397,0.000098802,0.0001266946,0.0001699581,0.00007374947,0.00001033207,0.000006850666,0.00009319973],"genre_scores_gemma":[0.9963994,0.002991602,0.0002800782,0.000149283,0.00009611411,0.000003209092,0.000006215543,0.00001437598,0.00005974345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03392418,"threshold_uncertainty_score":0.4726312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0504872898028882,"score_gpt":0.325595727291733,"score_spread":0.2751084374888448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}