{"id":"W2772593011","doi":"10.1021/acs.biomac.7b01475","title":"Well-Defined Cationic <i>N</i>-[3-(Dimethylamino)propyl]methacrylamide Hydrochloride-Based (Co)polymers for siRNA Delivery","year":2017,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Chulalongkorn University","keywords":"Methacrylamide; Cationic polymerization; Chemistry; Polymer; Hydrochloride; Polymer chemistry; Organic chemistry; Copolymer; Acrylamide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002603974,0.0003900161,0.0002991894,0.0001112618,0.0006731358,0.0002274365,0.000935206,0.0002966455,0.00004908749],"category_scores_gemma":[0.0002295823,0.0003868885,0.0003735001,0.00005822969,0.0003289271,0.00001956209,0.0001540449,0.0000912894,0.00008823661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003398885,"about_ca_system_score_gemma":0.000239077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002070625,"about_ca_topic_score_gemma":0.0001249655,"domain_scores_codex":[0.9979687,0.00005912418,0.0003944459,0.0007876996,0.0002218648,0.0005681596],"domain_scores_gemma":[0.9979364,0.00004299114,0.0003521093,0.001282168,0.0002221822,0.0001641148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003681963,0.0001031203,0.0008848324,0.00004417243,0.0001360996,0.0000156808,0.00001501389,0.00001984582,0.9858749,0.0001214192,0.003552368,0.008864339],"study_design_scores_gemma":[0.001411673,0.0005734243,0.001743988,0.00003424409,0.00006853429,0.00001425453,0.00002875933,0.0003437581,0.9639577,0.0002299463,0.03107572,0.0005179589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848965,0.001254093,0.008290921,0.0004681091,0.0005038409,0.0005233772,0.0001491231,0.00004733604,0.003866742],"genre_scores_gemma":[0.9938226,0.0001957202,0.002269145,0.0006482503,0.0003760712,0.0001594698,0.0005860946,0.00007028949,0.001872303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02752335,"threshold_uncertainty_score":0.9998583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969770649545262,"score_gpt":0.2896368370358504,"score_spread":0.2699391305403978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}