{"id":"W2772593011","doi":"10.1021/acs.biomac.7b01475","title":"Well-Defined Cationic <i>N</i>-[3-(Dimethylamino)propyl]methacrylamide Hydrochloride-Based (Co)polymers for siRNA Delivery","year":2017,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Chulalongkorn University","keywords":"Methacrylamide; Cationic polymerization; Chemistry; Polymer; Hydrochloride; Polymer chemistry; Organic chemistry; Copolymer; Acrylamide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002284855,0.000506036,0.0001894866,0.000195385,0.0001337054,0.0002880306,0.0002249028,0.0003783249,0.0006463754],"category_scores_gemma":[0.0001792452,0.0001813382,0.0001900955,0.0001420827,0.0001811077,0.0003522787,0.0001652249,0.0004198005,0.0005596144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002779615,"about_ca_system_score_gemma":0.0002494222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002019104,"about_ca_topic_score_gemma":0.0005241903,"domain_scores_codex":[0.9998173,0.00003413933,0.00002218774,0.00004039511,0.00005277436,0.00003320017],"domain_scores_gemma":[0.9998573,0.00002079663,0.00006316312,0.00001077317,0.00002141419,0.00002649418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001115464,0.000005386726,0.00001463774,0.00001614564,9.30642e-7,0.00001207006,0.000003132084,0.00004375977,0.9993622,0.00004665205,0.00001064249,0.0004733583],"study_design_scores_gemma":[0.000004948354,0.00007013742,0.0002459979,0.000002323976,0.000003952628,0.00006136672,0.000002924121,0.0005856891,0.9979593,0.00001504183,0.001044991,0.000003335259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9500265,0.004030027,0.04192779,0.0001139762,0.00006187413,0.0002530433,0.0002985033,0.0002575808,0.003030689],"genre_scores_gemma":[0.9604152,0.001899003,0.03361165,0.000078499,0.00002151775,0.0001940473,0.000376825,0.00005490523,0.003348435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006463754,"threshold_uncertainty_score":0.002162337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969770649545262,"score_gpt":0.2896368370358504,"score_spread":0.2699391305403978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}