{"id":"W2772633502","doi":"10.1016/j.thromres.2017.12.005","title":"Impact of age, comorbidity, and polypharmacy on the efficacy and safety of edoxaban for the treatment of venous thromboembolism: An analysis of the randomized, double-blind Hokusai-VTE trial","year":2017,"lang":"en","type":"article","venue":"Thrombosis Research","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute; Ottawa Hospital; University of Ottawa","funders":"Daiichi-Sankyo","keywords":"Edoxaban; Medicine; Warfarin; Polypharmacy; Concomitant; Comorbidity; Internal medicine; Hazard ratio; Intensive care medicine; Atrial fibrillation; Rivaroxaban; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004109725,0.0002909196,0.002575987,0.0003875647,0.0007362248,0.00007290666,0.0007540749,0.0001063346,0.0001272802],"category_scores_gemma":[0.0005554979,0.0001273891,0.0009010255,0.0005076708,0.002709072,0.00009147906,0.0003105079,0.0002331034,5.542185e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010051,"about_ca_system_score_gemma":0.0002009602,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01144629,"about_ca_topic_score_gemma":0.0004263864,"domain_scores_codex":[0.9965568,0.0007208876,0.0008362719,0.0004106622,0.001028102,0.0004472988],"domain_scores_gemma":[0.9927878,0.003887276,0.0007380386,0.001996851,0.0004470329,0.0001429576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8844724,0.01976804,0.008930773,0.0004483905,0.03852205,0.000003439372,0.0118845,0.0003271232,0.009219872,0.008191414,0.0007627414,0.0174692],"study_design_scores_gemma":[0.3975066,0.007303826,0.5771721,0.0001616329,0.008653643,9.24573e-7,0.0004817408,0.0008535632,0.007426344,0.0001939583,0.000122033,0.0001236741],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880645,0.000623307,0.00001186497,0.001674809,0.0001213128,0.008503547,0.0001705185,0.000006522139,0.0008235839],"genre_scores_gemma":[0.986191,0.01324871,0.00002722333,0.000020813,0.0001416272,0.0002732544,0.00001955772,0.00003095765,0.00004681958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5682413,"threshold_uncertainty_score":0.9981689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2503552024359164,"score_gpt":0.4964875795836853,"score_spread":0.2461323771477689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}