{"id":"W2772633502","doi":"10.1016/j.thromres.2017.12.005","title":"Impact of age, comorbidity, and polypharmacy on the efficacy and safety of edoxaban for the treatment of venous thromboembolism: An analysis of the randomized, double-blind Hokusai-VTE trial","year":2017,"lang":"en","type":"article","venue":"Thrombosis Research","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute; Ottawa Hospital; University of Ottawa","funders":"Daiichi-Sankyo","keywords":"Edoxaban; Medicine; Warfarin; Polypharmacy; Concomitant; Comorbidity; Internal medicine; Hazard ratio; Intensive care medicine; Atrial fibrillation; Rivaroxaban; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005390521,0.001273423,0.004698686,0.0003345269,0.0004318139,0.0014539,0.0009294757,0.001802097,0.002556636],"category_scores_gemma":[0.006162782,0.0007322807,0.004702963,0.0004973988,0.001562128,0.001360793,0.0006465048,0.002893964,0.0002565425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000740849,"about_ca_system_score_gemma":0.001082188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110506,"about_ca_topic_score_gemma":0.001663202,"domain_scores_codex":[0.9965108,0.002310216,0.0003114385,0.000428078,0.000221664,0.0002177426],"domain_scores_gemma":[0.99452,0.003203182,0.001013027,0.0005423166,0.000170749,0.0005507568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9850654,0.000836779,0.002582075,0.0003923634,0.005093621,0.00001965806,0.00002701229,0.0002202087,0.0004977856,0.00007000924,0.0001385933,0.005056511],"study_design_scores_gemma":[0.9292912,0.03227328,0.0195842,0.00008180703,0.01615947,0.00007338388,0.00005149162,0.001106536,0.0005847081,0.0003452881,0.0003872015,0.000061429],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894915,0.008498019,0.0003068025,0.0002672284,0.0002104125,0.0002256039,0.0003807654,0.00002260819,0.0005971181],"genre_scores_gemma":[0.9957104,0.002219758,0.0004964557,0.0003393352,0.0002328028,0.0001577325,0.0004489173,0.0000105617,0.0003839586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005390521,"threshold_uncertainty_score":0.02850819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2503552024359164,"score_gpt":0.4964875795836853,"score_spread":0.2461323771477689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}