{"id":"W2772692099","doi":"10.1158/0008-5472.can-17-1679","title":"Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":235,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University Belfast; Queen's University; Wellcome Trust; Wellcome","keywords":"Transcription factor; Drug; Cancer drugs; Cancer; Cancer research; Sensitivity (control systems); Biology; Chemistry; Computational biology; Pharmacology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006384359,0.00007662478,0.0001156418,0.00006496382,0.0001364562,0.00003272964,0.0001512361,0.00008385802,0.00005456447],"category_scores_gemma":[0.00009103196,0.00007700492,0.00004363017,0.00005025237,0.0002125339,0.00001039012,0.00006575003,0.00015322,8.802815e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000564118,"about_ca_system_score_gemma":0.0001785441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004299748,"about_ca_topic_score_gemma":0.01602985,"domain_scores_codex":[0.9989996,0.0001520505,0.0001205753,0.0002501571,0.0002369858,0.0002406135],"domain_scores_gemma":[0.9993532,0.00002454494,0.00006899613,0.0003740033,0.0001329003,0.00004631757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001803647,0.00002587612,0.02747142,0.00004309426,0.00001600314,0.000001247473,0.0001561439,0.00005924775,0.9524173,0.000008740591,0.0001085238,0.01951203],"study_design_scores_gemma":[0.0001952814,0.00004977715,0.1347644,0.000040386,0.000002022398,6.826975e-8,0.000072077,0.00003049087,0.8627604,0.00005447723,0.001957903,0.00007262364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960365,0.002535494,0.0001170907,0.0002601359,0.0001505724,0.0001752548,0.00006642605,0.000002117921,0.0006563553],"genre_scores_gemma":[0.9938203,0.004788282,0.00003329158,0.000007509214,0.0001381901,0.00006488713,0.000008183873,0.00001276208,0.001126642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.107293,"threshold_uncertainty_score":0.8945033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06211322106196542,"score_gpt":0.4139242630047016,"score_spread":0.3518110419427362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}