{"id":"W2772844083","doi":"10.1159/000484633","title":"The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics","year":2017,"lang":"en","type":"article","venue":"American Journal of Nephrology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of British Columbia","funders":"Janssen Research and Development","keywords":"Medicine; Albuminuria; Canagliflozin; Kidney disease; Internal medicine; Renal function; Empagliflozin; Diabetes mellitus; Endocrinology; Type 2 diabetes; Diabetic nephropathy; Creatinine; Urology; Nephropathy; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01249708,0.002610899,0.002680459,0.0007711921,0.001047782,0.001991965,0.001927543,0.002486396,0.01404994],"category_scores_gemma":[0.01347102,0.0009515061,0.001774614,0.001124606,0.001664542,0.001701599,0.001392601,0.002529347,0.002692116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009284157,"about_ca_system_score_gemma":0.002709914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008525894,"about_ca_topic_score_gemma":0.001245768,"domain_scores_codex":[0.9936209,0.003930151,0.0003630201,0.0008826391,0.0007637184,0.0004395171],"domain_scores_gemma":[0.9966072,0.0009251427,0.0006600511,0.0003818493,0.0006343504,0.0007914157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.8850807,0.01057419,0.01989712,0.005248351,0.002439905,0.0002579956,0.0002150373,0.001447591,0.001825574,0.004643396,0.03254285,0.03582736],"study_design_scores_gemma":[0.8867596,0.03802193,0.02801459,0.000891198,0.002817205,0.0002326149,0.00009793801,0.002337402,0.0006713017,0.002885097,0.03716798,0.0001032725],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.3264218,0.01720612,0.0126913,0.007747306,0.003930493,0.5395216,0.04019098,0.0005815626,0.05170884],"genre_scores_gemma":[0.4025473,0.003970624,0.01631313,0.007041168,0.002965613,0.53236,0.02310099,0.00009422882,0.01160692],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01404994,"threshold_uncertainty_score":0.06609166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03088791966519221,"score_gpt":0.3256573267011754,"score_spread":0.2947694070359832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}