{"id":"W2772893411","doi":"10.1016/j.jns.2017.08.515","title":"Characteristic neurochemical changes in the substantia nigra (SN) and striatum of symptomatic versus asymptomatic dopa-responsive dystonia (DRD)","year":2017,"lang":"en","type":"article","venue":"Journal of the Neurological Sciences","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Brain Institute; University of Toronto","funders":"","keywords":"GTP cyclohydrolase I; Tetrahydrobiopterin; Tyrosine hydroxylase; Substantia nigra; Neurochemical; Biopterin; Striatum; Dystonia; Internal medicine; Endocrinology; Dopamine; Enzyme; Chemistry; Medicine; Neuroscience; Biochemistry; Cofactor; Biology; Dopaminergic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799086,0.0002376491,0.0002240495,0.0008113261,0.0002016601,0.0002828939,0.0001809939,0.0003521454,0.001216146],"category_scores_gemma":[0.0003438529,0.0001873771,0.0002158113,0.0002636118,0.0003770379,0.0001673388,0.0002188501,0.0002431267,0.0001517451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271083,"about_ca_system_score_gemma":0.0002571015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003177119,"about_ca_topic_score_gemma":0.005317295,"domain_scores_codex":[0.9999191,0.00001280732,0.00001175902,0.00001945702,0.00001975681,0.00001704219],"domain_scores_gemma":[0.9997894,0.0000314525,0.00005521992,0.00001156931,0.00003481747,0.00007756121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005585521,0.0001731304,0.09549864,0.0001914333,0.0002355901,0.007771272,0.0003484789,0.0002101626,0.8764475,0.0003259081,0.0002129774,0.01299938],"study_design_scores_gemma":[0.00004088115,0.0009271273,0.9495686,0.00001449579,0.0001133518,0.01821603,0.0003113301,0.000431845,0.02986683,0.0001666169,0.0003305607,0.00001229013],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980088,0.0004358461,0.0002054116,0.00001893789,0.000004876587,0.000007040209,0.0001954774,0.000009450409,0.001114159],"genre_scores_gemma":[0.9985223,0.0001953695,0.0003072293,0.00003476873,0.00000335313,0.000007931324,0.0003098153,0.000005314246,0.0006138455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003177119,"threshold_uncertainty_score":0.006317198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108219445960683,"score_gpt":0.2798797664064182,"score_spread":0.2587975719468114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}