{"id":"W2772898318","doi":"10.1099/jgv.0.000987","title":"Proprotein convertase subtilisin/kexin type 9 inhibits hepatitis C virus replication through interacting with NS5A","year":2017,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"NS5A; Proprotein convertase; Biology; Virology; Kexin; Hepatitis C virus; NS2-3 protease; PCSK9; Viral replication; Subtilisin; Hepacivirus; Cell biology; Virus; LDL receptor; Lipoprotein; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001432005,0.0002697064,0.0003315172,0.0001433063,0.0001499289,0.0002323308,0.0001822783,0.0002055987,0.0009813107],"category_scores_gemma":[0.0001264273,0.0001187887,0.0003445586,0.0001079544,0.0001794244,0.000112795,0.0001481728,0.0004935243,0.0003072347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002707895,"about_ca_system_score_gemma":0.0002505697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008379104,"about_ca_topic_score_gemma":0.001237183,"domain_scores_codex":[0.999818,0.00003622951,0.0000217326,0.00002323457,0.00005036099,0.00005042458],"domain_scores_gemma":[0.9999429,0.00001117727,0.00001266465,0.00000682032,0.000006938946,0.00001955351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004976653,0.0001410852,0.0003933126,0.00008045759,0.00002358241,0.00004720768,0.00001020683,0.0001257873,0.994481,0.00006530304,0.0001584551,0.003976025],"study_design_scores_gemma":[0.00008472038,0.0009199872,0.008641169,0.000007268718,0.00003375689,0.0002235316,0.00001471175,0.00306683,0.9844192,0.00004215416,0.002540298,0.000006313486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943095,0.002548152,0.00122856,0.0001438084,0.00005553092,0.00002451774,0.0001599694,0.00008030919,0.001449725],"genre_scores_gemma":[0.9957972,0.0009535813,0.0009324586,0.00005173492,0.00001377339,0.00002455337,0.0003117029,0.000009136617,0.001905844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009813107,"threshold_uncertainty_score":0.003282785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05661503480180696,"score_gpt":0.3797430108427488,"score_spread":0.3231279760409418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}