{"id":"W2772898318","doi":"10.1099/jgv.0.000987","title":"Proprotein convertase subtilisin/kexin type 9 inhibits hepatitis C virus replication through interacting with NS5A","year":2017,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"NS5A; Proprotein convertase; Biology; Virology; Kexin; Hepatitis C virus; NS2-3 protease; PCSK9; Viral replication; Subtilisin; Hepacivirus; Cell biology; Virus; LDL receptor; Lipoprotein; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000673224,0.0001696581,0.0004963849,0.0001449538,0.0002465231,0.00007575445,0.0003030277,0.0001650099,0.0003348677],"category_scores_gemma":[0.001939231,0.0001238544,0.00008991674,0.00008150525,0.0002497742,0.0005098805,0.0001064278,0.0007359178,0.00006596204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001492609,"about_ca_system_score_gemma":0.0003740002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002645003,"about_ca_topic_score_gemma":0.001241305,"domain_scores_codex":[0.9981564,0.0001731193,0.0005820449,0.0002904006,0.0004547661,0.0003433116],"domain_scores_gemma":[0.9973049,0.00007486993,0.0008676021,0.0008278561,0.0007336838,0.0001910834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004153518,0.0002767765,0.2766344,0.00007481859,0.0002689897,0.001541418,0.0005481936,0.00001801383,0.6784112,0.0002039691,0.004945567,0.03292314],"study_design_scores_gemma":[0.006142117,0.00941753,0.4347348,0.0004685083,0.0002024165,0.003554462,0.00003694268,0.001564191,0.4891121,0.0004393915,0.05395089,0.0003767058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915954,0.0002223934,0.0002919673,0.004983528,0.0003383677,0.0003539538,0.000006907184,0.00001382339,0.002193635],"genre_scores_gemma":[0.9920438,0.000646154,0.004714034,0.0008654195,0.0006981341,0.00001081159,0.00001052694,0.00003703731,0.0009740754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1892991,"threshold_uncertainty_score":0.5050637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05661503480180696,"score_gpt":0.3797430108427488,"score_spread":0.3231279760409418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}