{"id":"W2772950660","doi":"10.1038/s41598-017-16009-w","title":"The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Institute of General Medical Sciences; Fundamental Research Funds for the Central Universities; Zhejiang University","keywords":"Biology; Transcription factor; Homeobox protein NANOG; Inner cell mass; Trophoblast; Embryonic stem cell; Induced pluripotent stem cell; Gene regulatory network; Repressor; Cell biology; Genetics; Gene; Regulation of gene expression; CDX2; Blastocyst; Cellular differentiation; Cell fate determination; Gene expression; Embryogenesis; Homeobox; Placenta","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001896378,0.0001564145,0.0001347662,0.00003083637,0.002877926,0.0004440467,0.0006036664,0.00009872857,0.00001925973],"category_scores_gemma":[0.0001821757,0.0001034684,0.0001978077,0.00007832937,0.0005136147,0.00001658994,0.0002031894,0.0001129507,0.00000762626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003427864,"about_ca_system_score_gemma":0.0001826395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001945699,"about_ca_topic_score_gemma":0.00009955475,"domain_scores_codex":[0.9977973,0.00004350934,0.0005193854,0.0006793776,0.000540214,0.0004202109],"domain_scores_gemma":[0.9978309,0.0000385979,0.000484581,0.001299083,0.0002675576,0.00007926657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001528162,0.00006460866,0.00273494,0.00004209246,0.000043385,0.00002119541,0.0001254293,0.0005766666,0.9907411,0.00004783751,0.004460622,0.0009893546],"study_design_scores_gemma":[0.0002200253,0.00002968379,0.0100312,0.00002132806,0.000008004082,0.00006398588,0.00007402193,0.0002037808,0.6553805,0.0003426702,0.3335228,0.0001020134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906574,0.002046707,0.0002332529,0.0002705463,0.002185733,0.000997401,0.00001725626,0.00001066869,0.003580972],"genre_scores_gemma":[0.9848862,0.0001336644,0.0005436058,0.00001074964,0.0003796686,0.0001189069,0.0001198248,0.0000189675,0.01378844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3353606,"threshold_uncertainty_score":0.9984202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130832648445343,"score_gpt":0.2405286330595104,"score_spread":0.2292203065750569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}