{"id":"W2772964465","doi":"10.1158/0008-5472.can-17-1231","title":"Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Medical Research and Materiel Command; Canadian Institutes of Health Research; Terry Fox Research Institute; Canada Research Chairs; Government of Canada","keywords":"Prenylation; Statin; RHOB; HRAS; Geranylgeranylation; Fluvastatin; Cancer research; Farnesyl pyrophosphate; Mevalonate pathway; Cancer cell; Cancer; Mevalonic acid; Ectopic expression; Biology; Pharmacology; Signal transduction; Cell biology; Cell culture; RHOA; Biochemistry; Simvastatin; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001244233,0.0002280701,0.0003260128,0.000346913,0.0001885661,0.0002894665,0.0001286477,0.0002010814,0.001168072],"category_scores_gemma":[0.0001277965,0.000140667,0.0003801475,0.0003184498,0.0001689226,0.0001700813,0.0002990678,0.0003830207,0.0004336642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000252073,"about_ca_system_score_gemma":0.0002458287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006555682,"about_ca_topic_score_gemma":0.00114313,"domain_scores_codex":[0.9997874,0.00002721239,0.00002858361,0.00003550441,0.00008296181,0.00003836955],"domain_scores_gemma":[0.9999057,0.00001300972,0.00002606572,0.00002472128,0.00001795337,0.0000124737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009155468,0.00001140054,0.0002678365,0.00003628291,0.000009609201,0.00003409007,0.000006066877,0.00003824276,0.998487,0.00006162973,0.00002710437,0.0009290727],"study_design_scores_gemma":[0.000006461186,0.0001047253,0.006138084,0.000003998519,0.00001488123,0.0001654072,0.00001437919,0.0005125852,0.9911965,0.00004075324,0.001799393,0.000002788952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890182,0.002543683,0.004964667,0.0001461245,0.00003984639,0.00004717182,0.001334354,0.0002011456,0.001704843],"genre_scores_gemma":[0.994183,0.001012488,0.001595853,0.00006276131,0.000005152804,0.00003587345,0.001428729,0.00001455905,0.001661655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168072,"threshold_uncertainty_score":0.003907561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08952582082911523,"score_gpt":0.3929057072076376,"score_spread":0.3033798863785224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}