{"id":"W2773135401","doi":"10.3390/cancers9120167","title":"Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer","year":2017,"lang":"en","type":"review","venue":"Cancers","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation; Strong; Research Manitoba","keywords":"Ubiquitin; Carcinogenesis; Deubiquitinating enzyme; Cancer research; Suppressor; Cancer; Histone H2B; Biology; Histone; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003015214,0.0005907923,0.000790262,0.001569858,0.0002449268,0.0006351023,0.0004711065,0.0006081165,0.002809905],"category_scores_gemma":[0.0003419208,0.0002028954,0.0003621707,0.001453179,0.0002629027,0.0007081443,0.000550498,0.0009489313,0.001894649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004837469,"about_ca_system_score_gemma":0.0007267877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006397829,"about_ca_topic_score_gemma":0.001357127,"domain_scores_codex":[0.9998933,0.0000133949,0.00001540966,0.00001684721,0.00004608436,0.00001497518],"domain_scores_gemma":[0.9998863,0.00003318764,0.00002223944,0.000004489541,0.00003613364,0.00001759617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007568642,0.00004870185,0.0002445122,0.0117551,0.00009322685,0.0002703411,0.00004927791,0.0003189053,0.005247334,0.002938769,0.02365265,0.9553056],"study_design_scores_gemma":[0.0000111554,0.0000576837,0.0008566017,0.001145457,0.00006657594,0.001275823,0.00002691631,0.00006037807,0.001224264,0.000973011,0.9942899,0.00001219382],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002726266,0.9975944,0.0001680477,0.000184389,0.0001317096,0.000004533261,0.00003067277,0.00001210997,0.001601578],"genre_scores_gemma":[0.001274064,0.9973599,0.0001785192,0.0001189597,0.00007174518,0.000005163663,0.00004967577,0.000002045842,0.0009398731],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002809905,"threshold_uncertainty_score":0.00940007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05068623051697205,"score_gpt":0.3429990710091801,"score_spread":0.2923128404922081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}