{"id":"W2773135401","doi":"10.3390/cancers9120167","title":"Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer","year":2017,"lang":"en","type":"review","venue":"Cancers","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation; Strong; Research Manitoba","keywords":"Ubiquitin; Carcinogenesis; Deubiquitinating enzyme; Cancer research; Suppressor; Cancer; Histone H2B; Biology; Histone; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003314255,0.0005452039,0.001033854,0.0001574825,0.0001832877,0.0001131238,0.0003314068,0.0003999882,0.00007898043],"category_scores_gemma":[0.00006951056,0.0005263346,0.0001846145,0.00008011357,0.0003140492,0.0000162057,0.0002421518,0.0003135013,0.000004895214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005088637,"about_ca_system_score_gemma":0.0008419483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002454601,"about_ca_topic_score_gemma":0.0004556131,"domain_scores_codex":[0.997735,0.0001634862,0.0005149136,0.0009506351,0.0001653131,0.0004706144],"domain_scores_gemma":[0.9985785,0.00003391911,0.0005414691,0.0005897582,0.00006441653,0.0001919217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009815275,0.00002651979,0.00003294204,0.006438381,0.0001395062,0.00005214123,0.0001903204,0.000008441045,0.01050351,0.00009768073,0.003621278,0.9787911],"study_design_scores_gemma":[0.00066093,0.0001504534,0.00005495869,0.004615939,0.0001378361,0.00006810766,0.00003893318,0.00001510626,0.01492009,0.00003787539,0.9786419,0.000657815],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03335222,0.9641292,0.000003544255,0.00003527597,0.0002315381,0.0008923398,0.0004096654,0.00001826054,0.0009279253],"genre_scores_gemma":[0.01238471,0.9845018,0.00008837049,0.00006592849,0.0006018734,0.00055061,0.0003434002,0.00009443933,0.001368845],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9781333,"threshold_uncertainty_score":0.9997188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05068623051697205,"score_gpt":0.3429990710091801,"score_spread":0.2923128404922081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}