{"id":"W2773151400","doi":"10.1212/wnl.80.7_supplement.p07.126","title":"Siponimod (BAF312) for the Treatment of Secondary Progressive Multiple Sclerosis: Design of the Phase 3 EXPAND Trial (P07.126)","year":2013,"lang":"en","type":"article","venue":"Neurology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Multiple sclerosis; Medicine; Phase (matter); Physical medicine and rehabilitation; Immunology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002128812,0.00149831,0.001806283,0.0004289954,0.0005334779,0.000660801,0.0006335162,0.001473277,0.004929602],"category_scores_gemma":[0.0008186502,0.0003437918,0.0008961141,0.0003191299,0.0007275285,0.0007394768,0.0003598793,0.002241982,0.0008980047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005565714,"about_ca_system_score_gemma":0.001882393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006125313,"about_ca_topic_score_gemma":0.002169226,"domain_scores_codex":[0.9996042,0.0002123391,0.0000183838,0.00004247952,0.00004368529,0.00007898594],"domain_scores_gemma":[0.9995487,0.00008191038,0.00009261219,0.00003012099,0.00003335953,0.0002132708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.8376037,0.0250873,0.002748285,0.001000456,0.0008929467,0.0003071762,0.0001305547,0.001445041,0.03559374,0.0005198012,0.004724708,0.08994614],"study_design_scores_gemma":[0.7169402,0.2701904,0.005310406,0.00003700144,0.0002959418,0.0002148992,0.00001940208,0.0005919347,0.003468554,0.0002341645,0.002671747,0.00002527294],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9807544,0.002756268,0.001050618,0.0009177952,0.0002432219,0.008141315,0.001950639,0.0001881101,0.003997756],"genre_scores_gemma":[0.9724701,0.002503664,0.004946253,0.001633758,0.0006578059,0.01101545,0.002509834,0.0000428607,0.004220198],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.004929602,"threshold_uncertainty_score":0.01649117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04260950006766338,"score_gpt":0.2686935983355008,"score_spread":0.2260840982678374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}