{"id":"W2773167564","doi":"10.1038/s41467-017-02200-0","title":"RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging; National Institutes of Health; McGill University; U.S. Department of Veterans Affairs; David and Lucile Packard Foundation","keywords":"C9orf72; Ran; Stress granule; Translation (biology); Trinucleotide repeat expansion; FMR1; Eukaryotic translation; Neurodegeneration; Integrated stress response; Biology; Translational regulation; Frontotemporal dementia; Cell biology; Genetics; Dementia; Medicine; Gene; Disease; Messenger RNA; Fragile x","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176094,0.0003013306,0.0001980089,0.0001655613,0.0001803111,0.000304842,0.000104024,0.000207016,0.001030064],"category_scores_gemma":[0.0001570339,0.0001048577,0.0002478328,0.00008329444,0.0002825481,0.0001487667,0.0001991835,0.000307729,0.0002271122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002924761,"about_ca_system_score_gemma":0.0001261594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004394724,"about_ca_topic_score_gemma":0.000996906,"domain_scores_codex":[0.9998287,0.00003823999,0.00001216978,0.00003491534,0.00004110937,0.00004489644],"domain_scores_gemma":[0.9998918,0.00002157523,0.00004093615,0.000009398484,0.00001337461,0.00002301019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009674669,0.0000092807,0.0003794113,0.000006890651,0.000003904335,0.00007630751,0.000004847901,0.00005088201,0.9990492,0.0000288722,0.00001795081,0.0002757348],"study_design_scores_gemma":[0.0000112891,0.0003511236,0.01751838,0.000006285793,0.00001482323,0.000548035,0.00003738649,0.001320462,0.9795116,0.00007035013,0.000602454,0.00000777834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988928,0.0001088806,0.0004886335,0.00002197849,0.000008367199,0.000004135894,0.00004867587,0.00002209253,0.0004044933],"genre_scores_gemma":[0.9989214,0.0000585306,0.0006322019,0.00001933084,0.000005623009,0.000005256036,0.00007899706,0.000008356513,0.0002703732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030064,"threshold_uncertainty_score":0.003445864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04894136879354989,"score_gpt":0.339509080123274,"score_spread":0.2905677113297241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}