{"id":"W2773253161","doi":"10.1056/nejmoa1708538","title":"Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant","year":2017,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":759,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Heart, Lung, and Blood Institute","keywords":"Medicine; Factor IX; Clotting factor; Intervention (counseling); Genetic enhancement; Medical therapy; Internal medicine; Gene; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002272446,0.0001610612,0.0002892648,0.00009297467,0.00008456965,0.000217509,0.000140593,0.0002211016,0.001864276],"category_scores_gemma":[0.000293532,0.00004803324,0.0001121223,0.0001786543,0.000241251,0.0001325903,0.00009201109,0.0002525166,0.0002471627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001466344,"about_ca_system_score_gemma":0.00008721859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002664934,"about_ca_topic_score_gemma":0.0002259978,"domain_scores_codex":[0.9998902,0.00002793963,0.000006274932,0.00002523787,0.00003100071,0.00001926676],"domain_scores_gemma":[0.9999425,0.00001486823,0.00002175121,0.00000664041,0.000003893204,0.00001028404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01180417,0.003198872,0.04958026,0.0005630331,0.0004643452,0.001343762,0.0004997525,0.0008352472,0.7151389,0.001776714,0.002712758,0.2120822],"study_design_scores_gemma":[0.009482007,0.1714553,0.2959993,0.0002230148,0.001246973,0.0334487,0.0005951016,0.009566517,0.4090244,0.001722369,0.06715319,0.00008319717],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974247,0.0008191866,0.000866961,0.00008050835,0.00001731648,0.00002860652,0.0000422623,0.00002509217,0.0006952976],"genre_scores_gemma":[0.9986071,0.0002333235,0.0005307943,0.00004381641,0.00001069531,0.00001879244,0.00006842471,0.000004871058,0.0004821288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001864276,"threshold_uncertainty_score":0.006236672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0630329570200211,"score_gpt":0.3256143882645576,"score_spread":0.2625814312445365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}