{"id":"W2773253161","doi":"10.1056/nejmoa1708538","title":"Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant","year":2017,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":759,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Heart, Lung, and Blood Institute","keywords":"Medicine; Factor IX; Clotting factor; Intervention (counseling); Genetic enhancement; Medical therapy; Internal medicine; Gene; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006165687,0.0002331592,0.0007424855,0.0001915694,0.000231744,0.00003540377,0.0002510268,0.00009611154,0.0008296797],"category_scores_gemma":[0.0001920294,0.0001104251,0.00009457813,0.00008592182,0.0002738239,0.0001833354,0.00002837851,0.0005594073,0.00001295091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008545971,"about_ca_system_score_gemma":0.000346008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002204236,"about_ca_topic_score_gemma":0.00001642917,"domain_scores_codex":[0.9981121,0.00007651495,0.0003405116,0.000202967,0.0009454263,0.0003224775],"domain_scores_gemma":[0.9979159,0.0001448932,0.0004069452,0.0005795583,0.0003178625,0.0006349036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01810067,0.0007044222,0.04203279,0.00005126747,0.0009796913,0.0123189,0.001355255,0.000002883225,0.1496452,0.0002244666,0.006473747,0.7681107],"study_design_scores_gemma":[0.2269974,0.01776192,0.516733,0.000905822,0.0002339862,0.009539953,0.00006925785,0.0000206695,0.04345742,0.0004766211,0.1834991,0.0003048225],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533424,0.001470727,0.0005235313,0.04195884,0.0005322175,0.0002676181,0.000004405452,0.00001361846,0.001886669],"genre_scores_gemma":[0.9846168,0.004221547,0.001234832,0.0001702994,0.007208092,0.000001634541,0.000003695034,0.00002978508,0.002513378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7678059,"threshold_uncertainty_score":0.9084411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0630329570200211,"score_gpt":0.3256143882645576,"score_spread":0.2625814312445365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}