{"id":"W2773291418","doi":"10.1126/scitranslmed.aan8848","title":"A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection","year":2017,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Maple Leaf Medical Clinic","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Medicine; Antiretroviral therapy; Human immunodeficiency virus (HIV); Clinical trial; Randomized controlled trial; Vaccination; Intensive care medicine; Immunology; Internal medicine; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004253255,0.0001520136,0.0009141723,0.0008267666,0.0002764221,0.00002345009,0.0002547354,0.00009928102,0.0003847611],"category_scores_gemma":[0.001460364,0.00009810005,0.000106768,0.0004700981,0.001145635,0.0003750498,0.00001323519,0.0002372861,0.00002332624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005136772,"about_ca_system_score_gemma":0.000316383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008501442,"about_ca_topic_score_gemma":0.0001442705,"domain_scores_codex":[0.9977201,0.0007108932,0.0007178226,0.0002739353,0.0002648594,0.0003124177],"domain_scores_gemma":[0.9981763,0.001080563,0.0003220959,0.0002214027,0.0001696838,0.00002995357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7587144,0.0007554213,0.1812093,0.000007567864,0.0002001682,0.000004182095,0.002562842,0.00002946004,0.0251516,0.003011405,0.00000482238,0.02834884],"study_design_scores_gemma":[0.5145981,0.000563092,0.4834649,0.00005240684,0.0000165556,0.000001117063,0.000008456776,0.00005855953,0.0006951929,0.0004806503,0.00001429554,0.00004673816],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926797,0.000629329,0.0001918569,0.001544779,0.000283514,0.002748094,0.00001812096,0.00001623272,0.001888373],"genre_scores_gemma":[0.9992614,0.000379958,0.00001202777,0.00002315987,0.00002863337,0.0001191237,0.00009727102,0.000005609067,0.00007277336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3022556,"threshold_uncertainty_score":0.4221141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04669643781445716,"score_gpt":0.3603787859578285,"score_spread":0.3136823481433714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}