{"id":"W2773311435","doi":"10.1002/anie.201711308","title":"A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation","year":2017,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust; Wellcome","keywords":"Nucleophile; Lactone; Chemistry; Hydrolysis; Serine; Enzyme; Stereochemistry; Carbapenem; Catalysis; Combinatorial chemistry; Mechanism (biology); Antibiotics; Organic chemistry; Biochemistry; Philosophy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004016479,0.000876263,0.0005464304,0.0003823094,0.0004400281,0.00152029,0.0009213458,0.001555126,0.002836681],"category_scores_gemma":[0.0004085278,0.0004138665,0.0006396314,0.0002013554,0.001382668,0.003835272,0.001306975,0.001230508,0.001362141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007035047,"about_ca_system_score_gemma":0.0005263732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003040377,"about_ca_topic_score_gemma":0.0002141167,"domain_scores_codex":[0.9996357,0.00004357831,0.00004198286,0.0001266122,0.00008063019,0.00007150685],"domain_scores_gemma":[0.9998023,0.00004015828,0.00005379735,0.00003524662,0.00002394701,0.00004457367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002196317,0.0001361279,0.00146267,0.0008864335,0.00004862471,0.001418256,0.0001942912,0.0004851819,0.9204955,0.04443748,0.001580875,0.02863494],"study_design_scores_gemma":[0.0001503943,0.001574829,0.001431036,0.00008280185,0.00005346538,0.006150507,0.0002217093,0.00480675,0.9023718,0.01396023,0.06911083,0.0000856765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5851847,0.05693625,0.29279,0.00927123,0.003435602,0.0005659352,0.0006246864,0.002220749,0.04897084],"genre_scores_gemma":[0.9180728,0.01840479,0.04397259,0.001966613,0.0003302476,0.0002011382,0.0002223072,0.00006837106,0.01676116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002836681,"threshold_uncertainty_score":0.009489596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02342853931615425,"score_gpt":0.2974392163938119,"score_spread":0.2740106770776576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}