{"id":"W2773514102","doi":"10.1038/nm.4439","title":"The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions","year":2017,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":875,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Biology; KRAS; Neuroblastoma RAS viral oncogene homolog; Myeloid leukemia; Cancer research; Genetics; DNA methylation; STK11; Gene; microRNA; Mutation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861949,0.0001938738,0.0002095731,0.0004317004,0.000161902,0.0004189101,0.0001829466,0.0002184038,0.002555952],"category_scores_gemma":[0.0003822085,0.0001345059,0.0001697984,0.000487015,0.0002132965,0.0003795535,0.0002625278,0.0002517274,0.0003668567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002233184,"about_ca_system_score_gemma":0.0001461531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000437447,"about_ca_topic_score_gemma":0.0008156664,"domain_scores_codex":[0.9998229,0.00002221367,0.000009953945,0.00004674808,0.00004617051,0.00005200901],"domain_scores_gemma":[0.9998274,0.00002582656,0.00009759836,0.00001391977,0.00001357252,0.00002160592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008159898,0.00006223917,0.2737277,0.0001274948,0.0002329992,0.002374239,0.0005103862,0.002153313,0.6380727,0.003240286,0.001718528,0.07696414],"study_design_scores_gemma":[0.00001864835,0.0002522365,0.9347895,0.00001806464,0.0001467738,0.007636208,0.0004054467,0.001767671,0.04243222,0.001432652,0.01108233,0.00001827228],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958307,0.001633681,0.0005817817,0.000134974,0.000007334965,0.000003393842,0.000320572,0.00002718101,0.001460451],"genre_scores_gemma":[0.9982596,0.0007846581,0.0002810415,0.00004524499,0.00001207251,0.000002467953,0.0002237366,0.00001439707,0.0003768083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002555952,"threshold_uncertainty_score":0.008550584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839391499378195,"score_gpt":0.3467394608742709,"score_spread":0.3283455458804889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}