{"id":"W2773639323","doi":"10.1038/s41556-017-0002-2","title":"A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells","year":2017,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":215,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Pentose phosphate pathway; Gluconeogenesis; Glycogen; Glycolysis; Glycogenesis; Phosphoenolpyruvate carboxykinase; Glycogenolysis; Cell biology; Biology; Biochemistry; Glutathione; Carbohydrate metabolism; Glycogen synthase; Chemistry; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009623914,0.0002969435,0.0001833178,0.0002618298,0.0003306318,0.0008721872,0.0003650156,0.0002507154,0.002436938],"category_scores_gemma":[0.0001610906,0.0002253938,0.0002101312,0.0001675462,0.0003036489,0.0005231709,0.0005571205,0.0008255297,0.0007405613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006129681,"about_ca_system_score_gemma":0.0003022654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005635832,"about_ca_topic_score_gemma":0.001804215,"domain_scores_codex":[0.9998623,0.000009476851,0.000006216884,0.00004762972,0.00001792305,0.00005642996],"domain_scores_gemma":[0.9998859,0.00000829304,0.000030107,0.00001372834,0.0000152987,0.00004664646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004707046,0.00003159194,0.0009854853,0.00005298046,0.000008462632,0.00005673607,0.00002707799,0.0002611236,0.9916081,0.0008051693,0.0003404664,0.0053521],"study_design_scores_gemma":[0.00007560989,0.0002117499,0.03528838,0.00002494658,0.00003230933,0.0002484639,0.0001624266,0.003860502,0.9534917,0.0009128939,0.005672992,0.00001803798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904654,0.001779665,0.002500669,0.0002714655,0.00009788961,0.00002128498,0.0004988534,0.000200802,0.004163984],"genre_scores_gemma":[0.9960582,0.0003458564,0.0007438405,0.00005187904,0.00001545492,0.00001570816,0.0003218198,0.00005704779,0.002390283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002436938,"threshold_uncertainty_score":0.008152366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006234875112870385,"score_gpt":0.2408375842857952,"score_spread":0.2346027091729248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}