{"id":"W2773639323","doi":"10.1038/s41556-017-0002-2","title":"A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells","year":2017,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":215,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Pentose phosphate pathway; Gluconeogenesis; Glycogen; Glycolysis; Glycogenesis; Phosphoenolpyruvate carboxykinase; Glycogenolysis; Cell biology; Biology; Biochemistry; Glutathione; Carbohydrate metabolism; Glycogen synthase; Chemistry; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002022643,0.0001829161,0.0003457794,0.0001189363,0.0002845361,0.000021693,0.000250212,0.0008294986,0.000292226],"category_scores_gemma":[0.0001286314,0.0001437259,0.00009542169,0.0000540851,0.0003591679,0.0001875569,0.0001060302,0.0005570644,0.0001067211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001564821,"about_ca_system_score_gemma":0.00002236049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007322153,"about_ca_topic_score_gemma":0.00001961284,"domain_scores_codex":[0.9989526,0.0001559327,0.0003050784,0.0002804593,0.00002044434,0.0002854812],"domain_scores_gemma":[0.9988257,0.0000714444,0.0004619787,0.0004399598,0.0001819415,0.00001898642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002836847,0.00009150978,0.0001902537,0.00003299732,0.00007196717,8.324224e-7,0.0001401299,5.100231e-7,0.9664272,0.0003609887,0.006819084,0.02558083],"study_design_scores_gemma":[0.0009202422,0.0001910379,0.002436838,0.0000164571,0.00004008835,0.00002741696,0.00007657291,0.00003347818,0.7139792,0.00009255495,0.28207,0.0001161191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565648,0.01806753,0.00004276716,0.0003525698,0.006468174,0.0006861645,0.0000225668,0.0002126852,0.01758276],"genre_scores_gemma":[0.9898134,0.0008746721,0.00027522,0.0001499442,0.00004382409,0.00002861341,0.000189561,0.00001284142,0.008611868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2752509,"threshold_uncertainty_score":0.6397852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006234875112870385,"score_gpt":0.2408375842857952,"score_spread":0.2346027091729248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}