{"id":"W2773849850","doi":"10.1007/s00280-017-3494-3","title":"Phase I/II study of mocetinostat in combination with gemcitabine for patients with advanced pancreatic cancer and other advanced solid tumors","year":2017,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Mirati Therapeutics","keywords":"Gemcitabine; Medicine; Pancreatic cancer; Internal medicine; Adverse effect; Cancer; Clinical endpoint; Phases of clinical research; Gastroenterology; Maximum tolerated dose; Oncology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104848,0.001743066,0.003409239,0.0007664874,0.0006100173,0.001491521,0.001101269,0.001318032,0.004498533],"category_scores_gemma":[0.0006723955,0.0009913131,0.001953351,0.000827643,0.001309938,0.001303075,0.0004987695,0.004689998,0.000977553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001305916,"about_ca_system_score_gemma":0.002373584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002124689,"about_ca_topic_score_gemma":0.00634482,"domain_scores_codex":[0.9996217,0.0001473938,0.00001774484,0.00008101376,0.00002211958,0.0001098586],"domain_scores_gemma":[0.9994743,0.0000598695,0.00006850548,0.00004897085,0.00002423267,0.0003241145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7874609,0.08180457,0.005208686,0.0008942731,0.002134035,0.0002506381,0.0003212859,0.004346752,0.03173314,0.0005251569,0.00491527,0.08040535],"study_design_scores_gemma":[0.6567361,0.3282238,0.006298613,0.00004179024,0.0007042372,0.0001690076,0.00009286119,0.001124008,0.002925389,0.0002321887,0.003417681,0.00003437342],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883158,0.00291143,0.0007253474,0.0009485274,0.0002827315,0.002893339,0.001483477,0.000134753,0.002304581],"genre_scores_gemma":[0.9832131,0.003968597,0.002121631,0.001023229,0.0002241737,0.0028392,0.002826615,0.00007463145,0.003708679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004498533,"threshold_uncertainty_score":0.0150491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200696942343428,"score_gpt":0.3602316395150852,"score_spread":0.348224670091651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}