{"id":"W2774019689","doi":"10.1002/biot.201700381","title":"Solid‐Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies","year":2017,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Polyclonal antibodies; Antibody; Monoclonal antibody; Glycosylation; Glycan; Sialic acid; Chemistry; Biochemistry; Sialyltransferase; Enzyme; Sialidase; Galactosyltransferase; Glycoprotein; Biology; Neuraminidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004127779,0.0004981969,0.0004128443,0.0002953018,0.0001251108,0.0004742563,0.0003520897,0.0003649611,0.001330322],"category_scores_gemma":[0.0002583079,0.0002622303,0.0004543971,0.0002543605,0.0001999559,0.0002437248,0.0004484404,0.0006833369,0.001676883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002678817,"about_ca_system_score_gemma":0.0001986951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002259254,"about_ca_topic_score_gemma":0.0004214188,"domain_scores_codex":[0.9996698,0.00004192492,0.00002425472,0.00005625668,0.0001479864,0.00005976893],"domain_scores_gemma":[0.9998109,0.00004537044,0.00004698723,0.00003724081,0.00003339837,0.00002620109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002864327,0.00003386586,0.00009059587,0.00002477906,0.000005326494,0.00004358144,0.000008535384,0.00008882199,0.9950487,0.0001773397,0.000127134,0.004322726],"study_design_scores_gemma":[0.00001060679,0.00008022071,0.0003363885,0.000003165721,0.000007402541,0.0000978475,0.000006076819,0.0005470617,0.9939731,0.00007027999,0.004864598,0.000003289077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7718275,0.003657026,0.2049974,0.0005506296,0.000339593,0.0004060216,0.001135614,0.001598946,0.0154873],"genre_scores_gemma":[0.9100469,0.002669179,0.07517587,0.0002966699,0.00005485325,0.0001742483,0.002260387,0.0003166304,0.009005199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001330322,"threshold_uncertainty_score":0.004450321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05826895701570179,"score_gpt":0.3991262712211162,"score_spread":0.3408573142054144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}