{"id":"W2774019689","doi":"10.1002/biot.201700381","title":"Solid‐Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies","year":2017,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Polyclonal antibodies; Antibody; Monoclonal antibody; Glycosylation; Glycan; Sialic acid; Chemistry; Biochemistry; Sialyltransferase; Enzyme; Sialidase; Galactosyltransferase; Glycoprotein; Biology; Neuraminidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004696153,0.0001776373,0.0005169341,0.0003371155,0.0006795773,0.00006684117,0.0005102903,0.0003545143,0.000136787],"category_scores_gemma":[0.0007597091,0.0001268171,0.000155603,0.00008175938,0.0007458685,0.0001701834,0.000238947,0.0008021458,0.00002843922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003888489,"about_ca_system_score_gemma":0.0001485823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007395223,"about_ca_topic_score_gemma":0.00001247235,"domain_scores_codex":[0.9983976,0.00002326765,0.0005134363,0.0002281941,0.0003848516,0.0004526868],"domain_scores_gemma":[0.9985018,0.00004432605,0.0004514134,0.0006031482,0.0002607212,0.0001386041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007140004,0.0005955728,0.004068236,0.0002206091,0.0002379992,0.0003291121,0.0001261561,0.00000398428,0.9176142,0.001972006,0.001151191,0.07296693],"study_design_scores_gemma":[0.002355167,0.002333739,0.004254547,0.0006270302,0.000107898,0.003754182,0.0002116952,0.0006960342,0.9742962,0.003982685,0.007169351,0.0002114498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751865,0.001159874,0.0005174254,0.02146516,0.0003265312,0.0001701004,0.00001061934,0.00004789901,0.00111586],"genre_scores_gemma":[0.9911872,0.00157814,0.005432867,0.00008204667,0.0003815707,0.000002178304,0.000004292924,0.00001797409,0.001313799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07275547,"threshold_uncertainty_score":0.5226828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05826895701570179,"score_gpt":0.3991262712211162,"score_spread":0.3408573142054144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}