{"id":"W2774072082","doi":"10.1161/circ.116.suppl_16.ii_117-b","title":"Abstract 639: Destabilization Of The Open State Of <i>I</i> <sub> <i>Ks</i> </sub> Potassium Channels By A KCNQ1 V205M Missense Mutation Causes An Inherited Form Of LQTS In A Canadian Aboriginal Community","year":2007,"lang":"en","type":"article","venue":"Circulation","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Simon Fraser University; University of British Columbia","funders":"","keywords":"Missense mutation; Long QT syndrome; Depolarization; Patch clamp; Membrane potential; Potassium channel; Mutation; Medicine; Voltage clamp; Cardiac action potential; QT interval; Ion channel; Biophysics; Electrophysiology; Transmembrane domain; Reversal potential; Internal medicine; Endocrinology; Genetics; Repolarization; Biology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007706118,0.0002857638,0.0001655337,0.0001254189,0.0005792619,0.0002472546,0.0003226576,0.0003935193,0.002291269],"category_scores_gemma":[0.0002130711,0.00009767358,0.0002773402,0.000125498,0.0003338432,0.0001014311,0.0001952503,0.0004223689,0.0006654197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001677024,"about_ca_system_score_gemma":0.0008447241,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1218447,"about_ca_topic_score_gemma":0.1081428,"domain_scores_codex":[0.9998792,0.000005263214,0.000005853402,0.00001932809,0.00005207234,0.00003828177],"domain_scores_gemma":[0.999899,0.00001003609,0.00001796684,0.000007948032,0.00001896446,0.00004608133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002720795,0.00003631423,0.002122533,0.00002375219,0.000009574367,0.00143299,0.0001308676,0.0001164212,0.9940935,0.0001387468,0.0003340576,0.00128923],"study_design_scores_gemma":[0.0001366777,0.0007828128,0.2579897,0.00004142497,0.00009956241,0.00940664,0.0007702973,0.005631513,0.7131329,0.0003160403,0.01161986,0.00007262507],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976398,0.0000661813,0.0004024884,0.00007795721,0.00002268593,0.00001070678,0.0002558821,0.00002433223,0.001499906],"genre_scores_gemma":[0.9966238,0.0000739361,0.0004564479,0.00006749295,0.000007753141,0.00001045426,0.000308172,0.00002303034,0.002428954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8781553,"threshold_uncertainty_score":0.2422709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0169591072706602,"score_gpt":0.2760366695539337,"score_spread":0.2590775622832736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}