{"id":"W2774171294","doi":"10.1126/scitranslmed.aal3765","title":"Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis","year":2017,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; University Health Network","funders":"National Heart, Lung, and Blood Institute","keywords":"Myofibroblast; Fibrosis; Apoptosis; Fibroblast; Cancer research; Cell biology; Medicine; Immunology; Biology; Pathology; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632219,0.0003075442,0.0002641102,0.0002769051,0.00018048,0.0002157815,0.000140502,0.0002143806,0.0009459439],"category_scores_gemma":[0.0001034919,0.0001061587,0.0002044482,0.0001281602,0.000266942,0.0001557576,0.0001087764,0.0007082374,0.0002489907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001894385,"about_ca_system_score_gemma":0.0002391304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008885425,"about_ca_topic_score_gemma":0.001611665,"domain_scores_codex":[0.9998864,0.00002173396,0.00001111974,0.0000145261,0.00003298338,0.00003325989],"domain_scores_gemma":[0.9998988,0.00001955075,0.00002834646,0.00001067739,0.00001307635,0.00002949632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001973725,0.00006332676,0.0001604539,0.00001783058,0.000003906514,0.0000690591,0.000008203157,0.00004880305,0.9980845,0.00003727975,0.0000235142,0.001285728],"study_design_scores_gemma":[0.00007347456,0.001223716,0.004598666,0.000005746027,0.00001962425,0.0002854041,0.00003424982,0.0007999896,0.9921674,0.00003772899,0.000750348,0.000003626498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962084,0.000990535,0.001506497,0.00006376431,0.00002899178,0.00003476099,0.0001217072,0.0001102046,0.000935206],"genre_scores_gemma":[0.9971932,0.0005664051,0.0008188714,0.00002710601,0.00001141286,0.00001530238,0.0001588109,0.00001131736,0.00119764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009459439,"threshold_uncertainty_score":0.00316453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597563011321245,"score_gpt":0.2914262477377035,"score_spread":0.275450617624491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}