{"id":"W2774583854","doi":"10.12688/f1000research.13440.1","title":"Can circulating tumor DNA be used for direct and early stage cancer detection?","year":2017,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"Canadian Cancer Society","keywords":"Open peer review; Plant biology; Stage (stratigraphy); Circulating tumor DNA; Biology; Physiology; Cancer; Medicine; Neuroscience; Computational biology; Internal medicine; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01161835,0.0008184517,0.001233151,0.001709425,0.0003928269,0.002660748,0.001467901,0.006895569,0.003355105],"category_scores_gemma":[0.04550929,0.0004214714,0.0007168281,0.0006372097,0.00267368,0.003172535,0.0007620868,0.003612605,0.003045514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001103689,"about_ca_system_score_gemma":0.001087427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302927,"about_ca_topic_score_gemma":0.001663324,"domain_scores_codex":[0.9969634,0.001277985,0.0002288944,0.0004494954,0.0009598054,0.0001203547],"domain_scores_gemma":[0.9797775,0.01345436,0.0009835854,0.0008665872,0.004378575,0.0005394444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001822886,0.0001166009,0.0100344,0.002780292,0.0003018767,0.0007823901,0.0002419178,0.0004386509,0.00702122,0.009989245,0.323328,0.6431426],"study_design_scores_gemma":[0.0003678089,0.001001596,0.009554206,0.003074513,0.0005126565,0.002094463,0.0005515565,0.00212906,0.02147451,0.04381378,0.9151803,0.0002455552],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.005362655,0.3089767,0.02538388,0.5593296,0.09534826,0.0001318434,0.0005521132,0.0003001488,0.004614656],"genre_scores_gemma":[0.1126183,0.3848428,0.04499632,0.2588331,0.176504,0.0003204545,0.0007995894,0.0005060795,0.02057933],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01161835,"threshold_uncertainty_score":0.06144452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04873980691521051,"score_gpt":0.3602891135199502,"score_spread":0.3115493066047397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}