{"id":"W2774624088","doi":"10.1016/j.bbmt.2017.11.025","title":"Intravenous Busulfan Compared with Total Body Irradiation Pretransplant Conditioning for Adults with Acute Lymphoblastic Leukemia","year":2017,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Ottawa Hospital","funders":"Gamida Cell; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Janssen Scientific Affairs; Health Resources and Services Administration; Otsuka Pharmaceutical; Astellas Pharma; U.S. Department of Health and Human Services; Miltenyi Biotec; Patient-Centered Outcomes Research Institute; Incyte; Seattle Genetics; Telomere Diagnostics; Alexion Pharmaceuticals; bluebird bio; Jazz Pharmaceuticals; Sunesis; Medac; AstraZeneca; Genentech; Chimerix; U.S. Department of Defense; Medical College of Wisconsin; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Takeda Oncology; University of Minnesota; Merck; Spectrum Pharmaceuticals; Roswell Park Cancer Institute; Fred Hutchinson Cancer Research Center; St. Baldrick's Foundation; Genzyme; National Cancer Institute; Gilead Sciences; Leukemia and Lymphoma Society; U.S. Navy; Celgene; WellPoint; Health Research; National Marrow Donor Program; Bristol-Myers Squibb; Astellas Pharma US; Otsuka America Pharmaceutical; Amgen; Be The Match Foundation; MedImmune; Sanofi; Onyx Pharmaceuticals","keywords":"Medicine; Busulfan; Lymphoblastic Leukemia; Total body irradiation; Conditioning; Internal medicine; Leukemia; Oncology; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004254062,0.0001873662,0.0003274778,0.0001879094,0.00008432846,0.0002251826,0.0001531093,0.0001174545,0.001048311],"category_scores_gemma":[0.001198438,0.00006260056,0.0004025484,0.0002466981,0.0001163429,0.0002027906,0.0002098767,0.0005101538,0.00008901037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512936,"about_ca_system_score_gemma":0.0003231357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003999599,"about_ca_topic_score_gemma":0.001030136,"domain_scores_codex":[0.9997323,0.0001443673,0.00002768668,0.00002450825,0.00003632715,0.00003474867],"domain_scores_gemma":[0.9994734,0.0001517164,0.0002076375,0.00001892665,0.00001607927,0.0001322623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3402923,0.003856981,0.261053,0.0008291301,0.001843808,0.0001991768,0.0002214413,0.002221984,0.01007852,0.0005615683,0.001683232,0.3771589],"study_design_scores_gemma":[0.01910768,0.2644538,0.6887982,0.0002982017,0.003113561,0.000983521,0.0002898173,0.004977553,0.01048873,0.0006437708,0.00681614,0.00002888126],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996866,0.002498946,0.00009640059,0.00008324235,0.00002733912,0.00002272581,0.00005308613,0.000007092096,0.0003451439],"genre_scores_gemma":[0.9988014,0.000741871,0.0001137098,0.00004504956,0.00002668162,0.00002179381,0.000104341,0.000001600144,0.000143639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001048311,"threshold_uncertainty_score":0.003506899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00796957581910224,"score_gpt":0.2360802247450965,"score_spread":0.2281106489259943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}