{"id":"W2774624088","doi":"10.1016/j.bbmt.2017.11.025","title":"Intravenous Busulfan Compared with Total Body Irradiation Pretransplant Conditioning for Adults with Acute Lymphoblastic Leukemia","year":2017,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Ottawa Hospital","funders":"Gamida Cell; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Janssen Scientific Affairs; Health Resources and Services Administration; Otsuka Pharmaceutical; Astellas Pharma; U.S. Department of Health and Human Services; Miltenyi Biotec; Patient-Centered Outcomes Research Institute; Incyte; Seattle Genetics; Telomere Diagnostics; Alexion Pharmaceuticals; bluebird bio; Jazz Pharmaceuticals; Sunesis; Medac; AstraZeneca; Genentech; Chimerix; U.S. Department of Defense; Medical College of Wisconsin; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Takeda Oncology; University of Minnesota; Merck; Spectrum Pharmaceuticals; Roswell Park Cancer Institute; Fred Hutchinson Cancer Research Center; St. Baldrick's Foundation; Genzyme; National Cancer Institute; Gilead Sciences; Leukemia and Lymphoma Society; U.S. Navy; Celgene; WellPoint; Health Research; National Marrow Donor Program; Bristol-Myers Squibb; Astellas Pharma US; Otsuka America Pharmaceutical; Amgen; Be The Match Foundation; MedImmune; Sanofi; Onyx Pharmaceuticals","keywords":"Medicine; Busulfan; Lymphoblastic Leukemia; Total body irradiation; Conditioning; Internal medicine; Leukemia; Oncology; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011478,0.0002117785,0.0004110756,0.0001049905,0.0002693498,0.00002481892,0.00007384682,0.0001595076,0.00001036402],"category_scores_gemma":[0.000008290718,0.0001649621,0.00004473681,0.00004077195,0.0002769187,0.0001485872,0.000002287956,0.00008634593,9.544748e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002152266,"about_ca_system_score_gemma":0.0001688162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001244736,"about_ca_topic_score_gemma":0.0001168642,"domain_scores_codex":[0.9989302,0.00003168762,0.0003207066,0.0003418558,0.0001339621,0.0002415825],"domain_scores_gemma":[0.9991407,0.0001405274,0.0002792368,0.0002023143,0.0001312339,0.0001059387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02900623,0.0003479497,0.09262026,0.006340146,0.001915911,0.0003164908,0.007906958,0.0001146664,0.857149,0.002214303,0.000008374724,0.002059734],"study_design_scores_gemma":[0.0438447,0.008519224,0.6403449,0.003485585,0.008511048,0.00747478,0.0004836305,0.002504752,0.2840064,0.0001806007,0.00001235739,0.000632001],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972196,0.00007504165,0.02563797,0.0001073094,0.00007457572,0.0009938818,0.0005686739,0.00004322485,0.000303261],"genre_scores_gemma":[0.9921864,0.0003832603,0.005186945,0.00002662464,0.00005419799,0.00009582365,0.002018948,0.00002444491,0.00002332984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5731425,"threshold_uncertainty_score":0.6726958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00796957581910224,"score_gpt":0.2360802247450965,"score_spread":0.2281106489259943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}